Difference between revisions of "Invasive breast cancer"

Invasive breast cancer (view source)

687 bytes removed , 00:01, 6 December 2010

→‎Paget's disease: split-out into separate article

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 ==Paget's disease==
-===General===
+{{Main|Paget disease}}
-*Cells in the epithelium, i.e. skin, that look like they don't belong.
-*Associated with underlying breast carcinoma.<ref name=emed_pagets>URL: [http://emedicine.medscape.com/article/1101235-diagnosis http://emedicine.medscape.com/article/1101235-diagnosis]</ref>
-Note:
-*Extra-mammary Paget's disease is not assoc. with malignancy.
 ===Microscopic===
 Features:<ref name=emed_pagets/>
-*Epitheliod morphology (round/ovoid).
+*Cells in the epidermis:
-*Cells nested or single.
+**Epitheliod morphology (round/ovoid).
-*Clear/pale cytoplasm '''key feature''' - may also be eosinophilic.
+**Cells nested or single.
-*Large nucleoli.
+**Clear/pale cytoplasm '''key feature''' - may also be eosinophilic.
+**Large nucleoli.
 Images:
 *[http://commons.wikimedia.org/wiki/File:Extramammary_Pagets_disease_low.jpg Paget's disease - low mag. (WC)].
 *[http://commons.wikimedia.org/wiki/File:Extramammary_Pagets_disease_high.jpg Paget's disease - high mag. (WC)].
-===DDx===
-*Benign Toker cell hyperplasia.
-*Malignant melanoma.
-*Bowen disease.
-*Nipple duct adenoma (clinical DDx).
-===IHC===
-Panel:<ref name=emed_pagets/>
-*S-100 -ve, HMB-45 -ve (both typically +ve in melanoma).
-*CK7 +ve
-*CEA +ve (-ve in Bowen's disease, -ve in Toker cells).
-Additional:
-*HER2/neu - usually +ve.
-*CK5/6 -ve.<ref>RS. May 2010.</ref>
-**Usu. +ve in squamous cell carcinoma.
 ==Familial breast cancer==