Difference between revisions of "Invasive breast cancer"

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Invasive breast cancer (view source)

Revision as of 11:31, 14 February 2014

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==Apocrine carcinoma of the breast==
==Apocrine carcinoma of the breast==
===General===
{{Main|Apocrine carcinoma of the breast}}
*Need >=90% apocrine morphology.<ref name=Ref_BP217>{{Ref BP|217}}</ref>
 
===Microscopic===
Features:<ref name=Ref_BP217>{{Ref BP|217}}</ref>
*Prominent [[nucleoli]].
**Often multiple.<ref>{{Cite journal  | last1 = O'Malley | first1 = FP. | last2 = Bane | first2 = A. | title = An update on apocrine lesions of the breast. | journal = Histopathology | volume = 52 | issue = 1 | pages = 3-10 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02888.x | PMID = 18171412 }}</ref>
*Abundant granular eosinophilic cytoplasm.
*Architecture like invasive ductal carcinomas ''no special type''.
 
Images:
*[http://path.upmc.edu/cases/case209/micro.html Apocrine carcinoma (upmc.edu)].
 
===IHC===
Smaller tumours classically:<ref name=pmid16045781>{{Cite journal  | last1 = Honma | first1 = N. | last2 = Takubo | first2 = K. | last3 = Akiyama | first3 = F. | last4 = Sawabe | first4 = M. | last5 = Arai | first5 = T. | last6 = Younes | first6 = M. | last7 = Kasumi | first7 = F. | last8 = Sakamoto | first8 = G. | title = Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. | journal = Histopathology | volume = 47 | issue = 2 | pages = 195-201 | month = Aug | year = 2005 | doi = 10.1111/j.1365-2559.2005.02181.x | PMID = 16045781 }}</ref>
*AR +ve.
*[[GCDFP-15]] +ve.
Usually:<ref name=Ref_BP217>{{Ref BP|217}}</ref>
*ER -ve.
*PR -ve.


==Mucinous breast carcinoma==
==Mucinous breast carcinoma==
Michael
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