Difference between revisions of "Invasive breast cancer"

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Invasive breast cancer (view source)

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→‎Glycogen-rich clear cell carcinoma of the breast: split out
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==Glycogen-rich clear cell carcinoma of the breast==
==Glycogen-rich clear cell carcinoma of the breast==
*Abbreviated ''GRCC''.
*Abbreviated ''GRCC''.
===General===
{{Main|Glycogen-rich clear cell carcinoma of the breast}}
*Very rare.
*Possibly a variant of [[apocrine carcinoma of the breast|apocrine carcinoma]].<ref name=pmid7611537>{{Cite journal  | last1 = Hayes | first1 = MM. | last2 = Seidman | first2 = JD. | last3 = Ashton | first3 = MA. | title = Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. | journal = Am J Surg Pathol | volume = 19 | issue = 8 | pages = 904-11 | month = Aug | year = 1995 | doi =  | PMID = 7611537 }}
</ref>
*Prognosis usu. poor.
 
===Microscopic===
Features:
*Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.<ref name=pmid20551566>{{Cite journal  | last1 = Thondavadi | first1 = SR. | last2 = Krishnamurthy | first2 = J. | last3 = Gubbanna | first3 = VM. | title = A case report of glycogen-rich clear cell carcinoma of breast. | journal = Indian J Pathol Microbiol | volume = 53 | issue = 2 | pages = 374-5 | month =  | year =  | doi = 10.4103/0377-4929.64289 | PMID = 20551566 | URL = http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=2;spage=374;epage=375;aulast=Thondavadi }}</ref>
**Various architectural arrangements: cords, trabeculae, clusters, cribriform.
**Minimal nuclear pleomorphism.
 
Notes:
*Histologic appearance may be similar to ''[[hyalinizing clear cell carcinoma]]''.
 
DDx:
*Signet-ring carcinoma.
*Lipid-rich carcinoma.
*[[Apocrine carcinoma of the breast|Apocrine carcinoma]].
*[[Secretory carcinoma of the breast|Secretory carcinoma]].
 
Image:
*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2010_53_2_374_64289_f1.jpg GRCC (ijpmonline.org)].<ref name=pmid20551566/>
 
===Stains===
Features:<ref name=pmid20551566/>
*PAS +ve.
*PASD -ve.
 
Others:<ref name=pmid20551566/>
*Oil red O -ve.
**Lipid-rich carcinoma +ve.
 
===IHC===
Features:<ref name=pmid20551566/>
*BRST2 -ve.
**Apocrine carcinoma +ve.


==Secretory carcinoma of the breast==
==Secretory carcinoma of the breast==
Michael
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