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| ==Tubular carcinoma of the breast== | | ==Tubular carcinoma of the breast== |
| *[[AKA]] ''tubular carcinoma''. | | *[[AKA]] ''tubular carcinoma''. |
| ===General===
| | {{Main|Tubular carcinoma of the breast}} |
| Epidemiology:
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| *Typically excellent prognosis.
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| *Hormone receptors commonly present (ER +ve, PR +ve).
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| *Usually HER2 -ve.
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| *Classically seen in post-menopausal women.
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| Note:
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| *May be seen in association with [[lobular carcinoma in situ]] and columnar cell lesions - known as '''Rosen triad'''.<ref name=pmid18434766>{{Cite journal | last1 = Brandt | first1 = SM. | last2 = Young | first2 = GQ. | last3 = Hoda | first3 = SA. | title = The "Rosen Triad": tubular carcinoma, lobular carcinoma in situ, and columnar cell lesions. | journal = Adv Anat Pathol | volume = 15 | issue = 3 | pages = 140-6 | month = May | year = 2008 | doi = 10.1097/PAP.0b013e31816ff313 | PMID = 18434766 }}</ref>
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| **Memory device ''TLC'' = '''T'''ubular ca., '''L'''CIS, '''C'''olumnar cell lesions.
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| ===Microscopic===
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| Features:<ref name=Ref_PBoD1146>{{Ref PBoD|1146}}</ref><ref>URL: [http://www.bweems.com/nsj3mp2.jpg http://www.bweems.com/nsj3mp2.jpg].</ref><ref>URL: [http://surgpathcriteria.stanford.edu/breast/tubularcabr/ http://surgpathcriteria.stanford.edu/breast/tubularcabr/].</ref>
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| *Well-formed tubules.
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| **Typically have angled ducts - "prows" - '''important feature''' (low power).
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| **Myoepithelial cells absent - diagnostic - may be have to appreciated without IHC.
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| **>70% of the tumour cells should be adjacent to lumen.<ref name=pmid10836300>{{Cite journal | last1 = Stalsberg | first1 = H. | last2 = Hartmann | first2 = WH. | title = The delimitation of tubular carcinoma of the breast. | journal = Hum Pathol | volume = 31 | issue = 5 | pages = 601-7 | month = May | year = 2000 | doi = | PMID = 10836300 }}</ref>
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| *+/- Cribriform spaces.
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| *Apocrine snouts typical.
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| *+/-Calcification.
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| Notes:
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| *Prow = front of a ship.
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| *Looks benign to the uninitiated -- '''important'''.
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| DDx:
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| *[[Sclerosing adenosis]].
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| *[[Microglandular adenosis]].
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| Image:
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| *[http://radiology.uchc.edu/eAtlas/Breast/1714.htm Tubular carcinoma - (uchc.edu)].
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| ===IHC===
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| *ER +ve.
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| *PR +ve.
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| *HER2 -ve.
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| **HER2 positivity should prompt consideration of another diagnosis!
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| ==Metaplastic breast carcinoma== | | ==Metaplastic breast carcinoma== |