|
|
Line 33: |
Line 33: |
| ===Treatment=== | | ===Treatment=== |
| Overview: | | Overview: |
| *[[LSIL]]: nothing, as usually regress. | | *[[LSIL]]: follow-up, as it usually regress. |
| *[[HSIL]]: excision (e.g. cone, [[LEEP]], laser) + follow-up. | | *[[HSIL]]: excision (e.g. cone, [[LEEP]], laser) + follow-up. |
|
| |
|
Line 49: |
Line 49: |
| ==Microscopic== | | ==Microscopic== |
| ===Low-grade squamous intraepithelial lesion=== | | ===Low-grade squamous intraepithelial lesion=== |
| Features - LSIL:<ref name=Ref_PBoD1075-6>{{Ref PBoD|1075-6}}</ref>
| | {{Main|Low-grade squamous intraepithelial lesion}} |
| *"Koilocytic atypia":<ref name=Ref_GP146>{{Ref GP|146}}</ref>
| |
| **Cytoplasmic halos.
| |
| **Nuclear enlargement >=3:1 enlarged nucleus:normal nucleus.
| |
| **Nuclear membrane irregularities.
| |
| **Nuclear hyperchromasia.
| |
| **Coarse chromatin.
| |
| **Binucleation may be seen (cytopathic effect of [[HPV]]).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref>
| |
| | |
| Note:
| |
| *Atypical cells usually close to basement membrane.
| |
| **May be seen, focally, in the upper layers.<ref name=Ref_GP146>{{Ref GP|146}}</ref>
| |
|
| |
|
| ====Koilocytes versus benign squamous==== | | ====Koilocytes versus benign squamous==== |