Difference between revisions of "Squamous intraepithelial lesion of the uterine cervix"

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===Treatment===
===Treatment===
Overview:
Overview:
*[[LSIL]]: nothing, as usually regress.   
*[[LSIL]]: follow-up, as it usually regress.   
*[[HSIL]]: excision (e.g. cone, [[LEEP]], laser) + follow-up.
*[[HSIL]]: excision (e.g. cone, [[LEEP]], laser) + follow-up.


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==Microscopic==
==Microscopic==
===Low-grade squamous intraepithelial lesion===
===Low-grade squamous intraepithelial lesion===
Features - LSIL:<ref name=Ref_PBoD1075-6>{{Ref PBoD|1075-6}}</ref>
{{Main|Low-grade squamous intraepithelial lesion}}
*"Koilocytic atypia":<ref name=Ref_GP146>{{Ref GP|146}}</ref>
**Cytoplasmic halos.
**Nuclear enlargement >=3:1 enlarged nucleus:normal nucleus.
**Nuclear membrane irregularities.
**Nuclear hyperchromasia.
**Coarse chromatin.
**Binucleation may be seen (cytopathic effect of [[HPV]]).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref>
 
Note:
*Atypical cells usually close to basement membrane.
**May be seen, focally, in the upper layers.<ref name=Ref_GP146>{{Ref GP|146}}</ref>


====Koilocytes versus benign squamous====
====Koilocytes versus benign squamous====
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