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Difference between revisions of "Sertoli cell nodule"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sertoli_cell_nodule_high_mag.jpg | |||
| Width = | |||
| Caption = Sertoli cell nodule. [[H&E stain]]. | |||
| Synonyms = Pick's adenoma, testicular [[tubular adenoma]], tubular adenoma of the testis | |||
| Micro = unencapsulated nodules composed of well-formed tubules, +/eosinophilic (hyaline) blob in lumen (centre), cells - vaguely resemble immature Sertoli cells (bland hyperchromatic oval/round nuclei) but are stratified (somewhat like a [[tubular adenoma of the gastrointestinal tract]]) | |||
| Subtypes = | |||
| LMDDx = [[Sertoli cell tumour]], [[sex cord tumour with annular tubules]], [[gonadoblastoma]] | |||
| Stains = | |||
| IHC = alpha-inhibin +ve, PLAP -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[testis]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-undescended testis | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon in general | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental. | '''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental. | ||
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**May contain eosinophilic (hyaline) blob in lumen (centre). | **May contain eosinophilic (hyaline) blob in lumen (centre). | ||
*Cells - vaguely resemble immature Sertoli cells: | *Cells - vaguely resemble immature Sertoli cells: | ||
**Bland hyperchromatic oval/round nuclei that are stratified. | **Bland hyperchromatic oval/round nuclei that are stratified - somewhat like a [[tubular adenoma of the gastrointestinal tract]] - '''key feature'''. | ||
DDx:<ref name=pmid21107095/> | DDx:<ref name=pmid21107095/> | ||