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Difference between revisions of "Sertoli cell nodule"
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'''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental. | |||
It is also known as '''Pick's adenoma''', '''testicular tubular adenoma''' and '''tubular adenoma of the testis'''. | |||
==General== | |||
*Benign proliferation of Sertoli cells - associated with cryptorchidism (undescended testis). | |||
*Not composed of a clonal cell population, i.e. ''not'' neoplastic; thus, technically, should not be called an ''adenoma''.<ref name=Ref_DCHH227>{{Ref DCHH|227}}</ref> | |||
==Gross== | |||
*Usually an incidental finding, rarely presents as a testicular mass.<ref name=pmid21107095>{{Cite journal | last1 = Vallangeon | first1 = BD. | last2 = Eble | first2 = JN. | last3 = Ulbright | first3 = TM. | title = Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses. | journal = Am J Surg Pathol | volume = 34 | issue = 12 | pages = 1874-80 | month = Dec | year = 2010 | doi = 10.1097/PAS.0b013e3181fcab70 | PMID = 21107095 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_DCHH227>{{Ref DCHH|227}}</ref><ref>{{cite journal |author=Ricco R, Bufo P |title=[Histologic study of 3 cases of so-called tubular adenoma of the testis] |language=Italian |journal=Boll. Soc. Ital. Biol. Sper. |volume=56 |issue=20 |pages=2110–5 |year=1980 |month=October |pmid=6109541 |doi= |url=}}</ref> | |||
*Unencapsulated nodules composed of well-formed tubules. | |||
**May contain eosinophilic (hyaline) blob in lumen (centre). | |||
*Cells - vaguely resemble immature Sertoli cells: | |||
**Bland hyperchromatic oval/round nuclei that are stratified. | |||
DDx:<ref name=pmid21107095/> | |||
*[[Sertoli cell tumour]]. | |||
*[[Sex cord tumour with annular tubules]]. | |||
*[[Gonadoblastoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Sertoli_cell_nodule_high_mag.jpg | Sertoli cell nodule - high mag. (WC) | |||
Image:Sertoli_cell_nodule_low_mag.jpg | Sertoli cell nodule - low mag. (WC) | |||
</gallery> | |||
===IHC=== | |||
Features:<ref name=pmid21107095/> | |||
*Alpha-inhibin +ve (5/5 cases). | |||
*OCT3/4 -ve (5/5 cases). | |||
Other: | |||
*PLAP -ve. | |||
==Sign out== | |||
<pre> | |||
TESTICLE, LEFT, ORCHIECTOMY: | |||
- ATROPHIC TESTICLE. | |||
- SERTOLI CELL NODULES. | |||
- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA. | |||
- NEGATIVE FOR MALIGNANCY. | |||
COMMENT: | |||
The above findings are supported by immunostains. The tubules stain with alpha-inhibin and | |||
are negative for PLAP. | |||
</pre> | |||
==See also== | |||
*[[Testis]]. | |||
*[[Sertoli cell tumour]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Testis]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||