Difference between revisions of "Invasive breast cancer"

Jump to navigation Jump to search
m
m (→‎HER2 scoring: sortable)
Line 304: Line 304:
===HER2 scoring===  
===HER2 scoring===  
Immunohistochemical based testing:<ref name=Ref_Lester241-2>{{Ref Lester|241-2}}</ref><ref name=Lester3_87>{{Ref Lester3|87}}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf]. Accessed on: 27 November 2011.</ref>
Immunohistochemical based testing:<ref name=Ref_Lester241-2>{{Ref Lester|241-2}}</ref><ref name=Lester3_87>{{Ref Lester3|87}}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf]. Accessed on: 27 November 2011.</ref>
{| class="wikitable"
{| class="wikitable sortable"
| '''Score'''
! Score
| '''Staining intensity'''
! Staining intensity
| '''Cells stained (%)'''
! Cells stained (%)
| '''Membrane staining'''
! Membrane staining
| '''Management'''
! Management
| '''Percentage of cases'''
! Percentage of cases
|-
|-
| '''0'''
| '''0'''
| nil
| nil
| <=10%
| '''<=10%'''
| incomplete
| '''incomplete'''
| No HER2 blocker
| No HER2 blocker
| ~60%
| ~60%
Line 321: Line 321:
| '''1+'''
| '''1+'''
| minimal-to-weak
| minimal-to-weak
| >10%
| '''>10%'''
| incomplete
| '''incomplete'''
| No HER2 blocker
| No HER2 blocker
| ~10%
| ~10%
Line 328: Line 328:
| '''2+'''
| '''2+'''
| weak-to-moderate ''or'' intense
| weak-to-moderate ''or'' intense
| >10% weak-to-moderate ''or'' <=30% intense
| '''>10% ''and'' <=30%'''
| complete
| '''complete'''
| Needs [[SISH]] or [[FISH]]
| Needs [[SISH]] or [[FISH]]
| ~10%
| ~10%
Line 335: Line 335:
| '''3+'''
| '''3+'''
| intense & uniform staining (used to be ''strong'')
| intense & uniform staining (used to be ''strong'')
| >30% (used to ''>10%'')
| '''>30%''' (used to ''>10%'')
| complete
| '''complete'''
| HER2 blocker
| HER2 blocker
| ~20%
| ~20%
Line 349: Line 349:
ISH based testing:<ref name=Lester3_87>{{Ref Lester3|87}}</ref>
ISH based testing:<ref name=Lester3_87>{{Ref Lester3|87}}</ref>
{| class="wikitable"
{| class="wikitable"
| '''Result'''
! Result
| '''Ratio criteria'''
! Ratio criteria
| '''Gene copy number criteria'''
! Gene copy number criteria
|-
|-
| Positive
| Positive
48,830

edits

Navigation menu