Difference between revisions of "Invasive breast cancer"

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Invasive breast cancer (view source)

Revision as of 01:39, 1 May 2012

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→‎Subtyping breast cancer
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==Subtyping breast cancer==
==Subtyping breast cancer==
===DCIS versus LCIS===
Stains:
*E-cadherin +ve DCIS, -ve LCIS.<ref name=pmid18318578>{{cite journal |author=Yeh IT, Mies C |title=Application of immunohistochemistry to breast lesions |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=349-58 |year=2008 |month=March |pmid=18318578 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=349}}</ref>
*34betaE12 +ve perinuclear LCIS, -ve DCIS.<ref name=pmid18318578/>
*CAM5.2 peripheral stain = DCIS, perinuclear stain = LCIS.<ref name=pmid18318578/>
**CAM5.2 is against CK8.
*Beta-catenin -ve LCIS, +ve DCIS.<ref name=pmid18318578/>


*DCIS vs LCIS:<ref>{{cite journal |author=Yeh IT, Mies C |title=Application of immunohistochemistry to breast lesions |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=349-58 |year=2008 |month=March |pmid=18318578 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=349}}</ref>
===Lymphovascular invasion===
**E-cadherin (+ve DCIS, -ve LCIS).
{{Main|Lymphovascular invasion}}
**antibody 34betaE12 (+ve perinuclear LCIS, -ve DCIS).
*D2-40 - marks the lymphatic spaces.<ref>{{cite journal |author=Ordóñez NG |title=Podoplanin: a novel diagnostic immunohistochemical marker |journal=Adv Anat Pathol |volume=13 |issue=2 |pages=83-8 |year=2006 |month=March |pmid=16670463 |doi=10.1097/01.pap.0000213007.48479.94 |url=}}</ref><ref>{{cite journal |author=Kahn HJ, Marks A |title=A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors |journal=Lab. Invest. |volume=82 |issue=9 |pages=1255-7 |year=2002 |month=September |pmid=12218087 |doi= |url=}}</ref>
**CAM5.2 (peripheral stain = DCIS, perinuclear stain = LCIS).
***CAM5.2 is against CK8.
**Beta-catenin (-LCIS, +DCIS).
 
*D2-40:<ref>{{cite journal |author=Ordóñez NG |title=Podoplanin: a novel diagnostic immunohistochemical marker |journal=Adv Anat Pathol |volume=13 |issue=2 |pages=83-8 |year=2006 |month=March |pmid=16670463 |doi=10.1097/01.pap.0000213007.48479.94 |url=}}</ref><ref>{{cite journal |author=Kahn HJ, Marks A |title=A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors |journal=Lab. Invest. |volume=82 |issue=9 |pages=1255-7 |year=2002 |month=September |pmid=12218087 |doi= |url=}}</ref>
**Monoclonal antibody to podoplanin.
**Useful to assess lymphovascular invasion.
 
*ADH and DCIS:<ref name=Ref_Lester122>{{Ref Lester|122}}</ref>
**E-cadherin.
***Present in most epithelial cells.
***Lost in LCIS & invasive lobular carcinoma.
**SMMHC (smooth muscle cell myosin heavy chain).
***Marks myoepithelial cells.


==Treatment-related markers - overview==
==Treatment-related markers - overview==
Michael
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