Difference between revisions of "Invasive breast cancer"

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==Familial breast cancer==
==Familial breast cancer==
===Syndromes associated with breast cancer===
{| class="wikitable sortable"
! Gene
! Syndrome
! Other cancers
! Notes
|-
| BRCA1
| -
| male breast, ovarian, prostate, pancreas, fallopian tube
| younger individual vis-à-vis BRCA2
|-
| BRCA2
| -
| male breast, ovarian, prostate, pancreas, stomach, melanoma, gallbladder, bile duct, pharynx
| younger individual vis-à-vis BRCA2
|-
| TP53 (p53)
| [[Li-Fraumeni syndrome]] ([[AKA]] ''SBLA syndrome'')
| [[sarcoma]]s, brain cancer, larynx, lung, leukemia, [[adrenal cortical carcinoma]]
| -
|-
| CHEK2
| Li-Fraumeni variant
| see ''p53''
| -
|-
| STK11
| [[Peutz-Jeghers syndrome]]
| breast, GI carcinoma, [[Sertoli cell tumour]], [[Granulosa cell tumour]], [[SCTAT]]
| -
|-
| PTEN
| [[Cowden syndrome]]
| breast, thyroid (PTC), endometrial, renal, colorectal
| -
|-
| CDH1
|
| lobular carcinoma, gastric [[signet ring cell carcinoma]]
| -
|-
|}
===BRCA1 and BRCA2===
BRCA1 vs. BRCA2:<ref name=Ref_PBoD8_1078>{{Ref PBoD8|1078}}</ref>
BRCA1 vs. BRCA2:<ref name=Ref_PBoD8_1078>{{Ref PBoD8|1078}}</ref>
{| class="wikitable sortable"  
{| class="wikitable sortable"  
| Gene
! Gene
| Age
! Age
| Histology
! Histology
| Other cancers
! Other cancers
|-
|-
| BRCA1
| BRCA1
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|}
|}


Types of cancer assoc. with both BRCA1 and BRCA2:  
Types of cancer associated with both BRCA1 and BRCA2:  
*Ovarian, male breast, prostate, pancreas.
*Ovarian, male breast, prostate, pancreas.


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