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Difference between revisions of "Bone"
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→Paget disease of the bone: fix sp., +assoc. with GCT of bone
(→Paget disease of the bone: expand) |
(→Paget disease of the bone: fix sp., +assoc. with GCT of bone) |
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*Afflicts ~ 3% of population > 55 years old.<ref name=pmid22396921/> | *Afflicts ~ 3% of population > 55 years old.<ref name=pmid22396921/> | ||
*Leading cause of ''secondary [[osteosarcoma]]''. | *Leading cause of ''secondary [[osteosarcoma]]''. | ||
*Uncommonly associated with [[giant cell tumour of bone]].<ref name=pmid17437100>{{Cite journal | last1 = Hoch | first1 = B. | last2 = Hermann | first2 = G. | last3 = Klein | first3 = MJ. | last4 = Abdelwahab | first4 = IF. | last5 = Springfield | first5 = D. | title = Giant cell tumor complicating Paget disease of long bone. | journal = Skeletal Radiol | volume = 36 | issue = 10 | pages = 973-8 | month = Oct | year = 2007 | doi = 10.1007/s00256-007-0310-x | PMID = 17437100 }}</ref><ref name=pmid21319038>{{Cite journal | last1 = Karakida | first1 = K. | last2 = Ota | first2 = Y. | last3 = Aoki | first3 = T. | last4 = Akamatsu | first4 = T. | last5 = Kajiwara | first5 = H. | last6 = Hirabayashi | first6 = K. | title = Multiple giant cell tumors in maxilla and skull complicating Paget's disease of bone. | journal = Tokai J Exp Clin Med | volume = 35 | issue = 3 | pages = 112-7 | month = Sep | year = 2010 | doi = | PMID = 21319038 }}</ref> | |||
*[[Diagnosis]] based on radiology.<ref name=pmid22396921/> | *[[Diagnosis]] based on radiology.<ref name=pmid22396921/> | ||
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**Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | **Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | ||
*Increased osteoclast activity. | *Increased osteoclast activity. | ||
**Osteoclast = macrophage that | **Osteoclast = macrophage that reabsorbs bone matrix. | ||
Images: | Images: | ||