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Difference between revisions of "Bone"
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→Paget disease of the bone: expand
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(→Paget disease of the bone: expand) |
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===General=== | ===General=== | ||
*Benign - unlike [[Paget disease of the breast]]. | *Benign - unlike [[Paget disease of the breast]]. | ||
*Afflicts ~ 3% of population > 55 years old.<ref name=pmid22396921/> | |||
*Leading cause of ''secondary [[osteosarcoma]]''. | *Leading cause of ''secondary [[osteosarcoma]]''. | ||
*[[Diagnosis]] based on radiology.<ref name=pmid22396921/> | |||
Classically divided into three phases:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref><ref>URL: [http://radiopaedia.org/articles/paget-disease-of-bone-1 http://radiopaedia.org/articles/paget-disease-of-bone-1]. Accessed on: 25 December 2010.</ref> | Classically divided into three phases:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref><ref>URL: [http://radiopaedia.org/articles/paget-disease-of-bone-1 http://radiopaedia.org/articles/paget-disease-of-bone-1]. Accessed on: 25 December 2010.</ref> | ||
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#Sclerotic (burned-out). | #Sclerotic (burned-out). | ||
Clinical: | ====Clinical==== | ||
Presentation:<ref name=pmid22396921>{{Cite journal | last1 = Britton | first1 = C. | last2 = Walsh | first2 = J. | title = Paget disease of bone - an update. | journal = Aust Fam Physician | volume = 41 | issue = 3 | pages = 100-3 | month = Mar | year = 2012 | doi = | PMID = 22396921 | URL = http://www.racgp.org.au/afp/201203/201203britton.pdf }}</ref> | |||
*[[Fracture of bone|Fracture]]. | |||
*Bone pain. | |||
*Bony deformity. | |||
*Deafness. | |||
*Incidental finding - radiologic or biochemical. | |||
Serology: | |||
*Elevated ALP. | *Elevated ALP. | ||