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Difference between revisions of "Invasive breast cancer"
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→Medullary breast carcinoma: more
(→Molecular classification of invasive carcinoma: tweak wording) |
(→Medullary breast carcinoma: more) |
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*[[AKA]] ''medullary carcinoma of the breast''. | *[[AKA]] ''medullary carcinoma of the breast''. | ||
===General=== | ===General=== | ||
*Uncommon breast cancer subtype. | |||
*Some pathologists don't believe this exists. | *Some pathologists don't believe this exists. | ||
Epidemiology: | Epidemiology: | ||
*Thought to have a better prognosis that no special type (NST). | *Thought to have a better prognosis that no special type (NST). | ||
* | *May be associated with a BRCA1 mutation. | ||
===Gross=== | |||
*Well-circumscribed border.<ref name=pmid21071383>{{Cite journal | last1 = Yoo | first1 = JL. | last2 = Woo | first2 = OH. | last3 = Kim | first3 = YK. | last4 = Cho | first4 = KR. | last5 = Yong | first5 = HS. | last6 = Seo | first6 = BK. | last7 = Kim | first7 = A. | last8 = Kang | first8 = EY. | title = Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? | journal = Radiographics | volume = 30 | issue = 6 | pages = 1689-702 | month = Oct | year = 2010 | doi = 10.1148/rg.306105511 | PMID = 21071383 }}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
| Line 361: | Line 365: | ||
#High nuclear grade (as per Nottingham grading system). | #High nuclear grade (as per Nottingham grading system). | ||
#No tubule formation. | #No tubule formation. | ||
===IHC=== | |||
Features - typical:<ref>{{Cite journal | last1 = Matkovic | first1 = B. | last2 = Juretic | first2 = A. | last3 = Separovic | first3 = V. | last4 = Novosel | first4 = I. | last5 = Separovic | first5 = R. | last6 = Gamulin | first6 = M. | last7 = Kruslin | first7 = B. | title = Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer. | journal = Tumori | volume = 94 | issue = 6 | pages = 838-44 | month = | year = | doi = | PMID = 19267102 }}</ref> | |||
*ER -ve. | |||
*PR -ve. | |||
*HER2 -ve. | |||
==Tubular carcinoma of the breast== | ==Tubular carcinoma of the breast== | ||