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Difference between revisions of "Haematopathology"
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→Plasmacytoma
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==Plasmacytoma== | ==Plasmacytoma== | ||
===General=== | ===General=== | ||
*[[AKA]] ''plasma cell myleoma''. | |||
*Malignancy derived from the plasma cells. | *Malignancy derived from the plasma cells. | ||
*Histologic component of ''multiple myeloma''; to diagnose multiple myeloma other (non-pathology) criteria are needed. | *Histologic component of ''multiple myeloma''; to diagnose multiple myeloma other (non-pathology) criteria are needed. | ||
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===Microscopic=== | ===Microscopic=== | ||
* | Features: | ||
*Abundant eosinophilic cytoplasm. | |||
*Eccentrically placed nucleus - usually with "clock face" morphology. | |||
**"Clock face" morphology = chromatin clumps around the edge of the nucleus, like the numbers on a clock face. | |||
**May have nucleoli. | |||
*Russell bodies: | *Russell bodies: | ||
**Eosinophilic, large (10-15 micrometres), homogenous immunoglobulin-containing inclusions. | **Eosinophilic, large (10-15 micrometres), homogenous immunoglobulin-containing inclusions. | ||
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**Dutcher bodies are ''PAS stain'' +ve.<ref>URL: [http://www.thefreelibrary.com/Dutcher+bodies+in+chronic+synovitis-a083551789 http://www.thefreelibrary.com/Dutcher+bodies+in+chronic+synovitis-a083551789]. Accessed on: 4 August 2010.</ref> | **Dutcher bodies are ''PAS stain'' +ve.<ref>URL: [http://www.thefreelibrary.com/Dutcher+bodies+in+chronic+synovitis-a083551789 http://www.thefreelibrary.com/Dutcher+bodies+in+chronic+synovitis-a083551789]. Accessed on: 4 August 2010.</ref> | ||
**Image [http://ashimagebank.hematologylibrary.org/cgi/content/full/2003/0227/100629 Dutcher bodies (hematologylibrary.org)]. | **Image [http://ashimagebank.hematologylibrary.org/cgi/content/full/2003/0227/100629 Dutcher bodies (hematologylibrary.org)]. | ||
*Prominent ''perinuclear hof'' - crescent shaped lucency | *Prominent ''perinuclear hof'' - cytoplasmic crescent shaped lucency adjacent to the nuclear membrane (due to large Golgi apparatus). | ||
Images: [http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)]. | Images: | ||
*[http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)]. | |||
*[http://commons.wikimedia.org/wiki/File:Plasmacytoma1.jpg Plasmacytoma (WC)]. | |||
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