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Difference between revisions of "Haematopathology"
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===IHC=== | ===IHC=== | ||
*CD45 | ====General==== | ||
*CD45. | |||
**AKA ''common lymphocyte antigen''. | **AKA ''common lymphocyte antigen''. | ||
**Useful to differentiate from carcinomas (e.g. small cell carcinoma). | **Useful to differentiate from carcinomas (e.g. small cell carcinoma). | ||
====T cell markers==== | |||
*CD2 -- T cell marker (all T cells). | |||
*CD3 -- T cell marker (all T cells). | *CD3 -- T cell marker (all T cells). | ||
**CD4 -- subset of T cells. | **CD4 -- subset of T cells. | ||
**CD8 -- subset of T cells. | **CD8 -- subset of T cells. | ||
*CD7 -- often lost first in T cell lymphomas. | |||
*CD5 -- +ve in CLL & mantle cell lymphoma. | |||
*CD43 -- +ve in mantle cell lymphoma | |||
====B cell markers=== | |||
*CD20 -- B cell marker. | *CD20 -- B cell marker. | ||
**CD19 -- B cell marker - used for [[flow cytometry]]. | **CD19 -- B cell marker - used for [[flow cytometry]]. | ||
*PAX-5. | |||
*CD79a. | |||
*CD10 -- follicule center. | *CD10 -- follicule center. | ||
* | *BCL-6. | ||
*BCL-2. | |||
====Follicular dendritic cells==== | |||
*CD23 -- follicular dendritic cells. | *CD23 -- follicular dendritic cells. | ||
*CD21 -- follicular dendritic cells. | *CD21 -- follicular dendritic cells. | ||
====Hodgkin's lymphoma==== | |||
=====Classic===== | |||
*CD30 -- Hodgkin's lymphoma (most sensitive). | |||
*CD15. | |||
==Hodgkin's lymphoma== | ==Hodgkin's lymphoma== | ||