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Difference between revisions of "Invasive breast cancer"
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→Adenoid cystic carcinoma of the breast: +glycogen-rich clear cell carcinoma
(fix naming) |
(→Adenoid cystic carcinoma of the breast: +glycogen-rich clear cell carcinoma) |
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Images: | Images: | ||
*[http://path.upmc.edu/cases/case140.html Adenoid cystic carcinoma of the breast (upmc.edu)]. | *[http://path.upmc.edu/cases/case140.html Adenoid cystic carcinoma of the breast (upmc.edu)]. | ||
==Glycogen-rich clear cell carcinoma of the breast== | |||
*Abbreviated ''GRCC''. | |||
===General=== | |||
*Very rare. | |||
*Possibly a variant of [[apocrine carcinoma]].<ref name=pmid7611537>{{Cite journal | last1 = Hayes | first1 = MM. | last2 = Seidman | first2 = JD. | last3 = Ashton | first3 = MA. | title = Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. | journal = Am J Surg Pathol | volume = 19 | issue = 8 | pages = 904-11 | month = Aug | year = 1995 | doi = | PMID = 7611537 }} | |||
</ref> | |||
===Microscopic=== | |||
Features: | |||
*Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.<ref name=pmid20551566>{{Cite journal | last1 = Thondavadi | first1 = SR. | last2 = Krishnamurthy | first2 = J. | last3 = Gubbanna | first3 = VM. | title = A case report of glycogen-rich clear cell carcinoma of breast. | journal = Indian J Pathol Microbiol | volume = 53 | issue = 2 | pages = 374-5 | month = | year = | doi = 10.4103/0377-4929.64289 | PMID = 20551566 | URL = http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=2;spage=374;epage=375;aulast=Thondavadi }}</ref> | |||
**Arranged in cords, trabeculae or clusters. | |||
**Minimal nuclear pleomorphism. | |||
*Hyalinized stroma. | |||
Notes: | |||
*Histologic appearance similar to ''[[hyalinizing clear cell carcinoma]]''. | |||
DDx: | |||
*Signet-ring carcinoma. | |||
*Lipid-rich carcinoma. | |||
*Apocrine carcinoma. | |||
*Secretory carcinoma. | |||
===Stains=== | |||
Features:<ref name=pmid20551566/> | |||
*PAS +ve. | |||
*PASD -ve. | |||
Others:<ref name=pmid20551566/> | |||
*Oil red O -ve. | |||
**Lipid-rich carcinoma +ve. | |||
===IHC=== | |||
Features:<ref name=pmid20551566/> | |||
*BRST2 -ve. | |||
**Apocrine carcinoma +ve. | |||
=Grading breast cancer= | =Grading breast cancer= | ||