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Pediatric gastrointestinal pathology (view source)
Revision as of 04:56, 28 December 2011
, 04:56, 28 December 2011→General: more still
(→Giant cell hepatitis: expand, links to images) |
(→General: more still) |
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===General=== | ===General=== | ||
*Rare. | *Rare. | ||
* | |||
Etiology: | |||
*Unknown - possibly viral, autoimmune and/or drugs.<ref name=pmid21043007>{{Cite journal | last1 = Hartl | first1 = J. | last2 = Buettner | first2 = R. | last3 = Rockmann | first3 = F. | last4 = Farkas | first4 = S. | last5 = Holstege | first5 = A. | last6 = Vogel | first6 = C. | last7 = Schnitzbauer | first7 = A. | last8 = Schlitt | first8 = HJ. | last9 = Schoelmerich | first9 = J. | title = Giant cell hepatitis: an unusual cause of fulminant liver failure. | journal = Z Gastroenterol | volume = 48 | issue = 11 | pages = 1293-6 | month = Nov | year = 2010 | doi = 10.1055/s-0029-1245476 | PMID = 21043007 }}</ref> | |||
*One large series suggests that, in the neonatal population, with follow-up the causes are: | |||
**~49% idiopathic. | |||
**~16% pan-hypopituitarism. | |||
**~8% biliary atresia. | |||
**~6% Alagille syndrome | |||
**~6% bile salt defects. | |||
Notes: | Notes: | ||
*May be seen in adults.<ref name=pmid21325763>{{Cite journal | last1 = Hayashi | first1 = H. | last2 = Narita | first2 = R. | last3 = Hiura | first3 = M. | last4 = Abe | first4 = S. | last5 = Tabaru | first5 = A. | last6 = Tanimoto | first6 = A. | last7 = Sasaguri | first7 = Y. | last8 = Harada | first8 = M. | title = A case of adult autoimmune hepatitis with histological features of giant cell hepatitis. | journal = Intern Med | volume = 50 | issue = 4 | pages = 315-9 | month = | year = 2011 | doi = | PMID = 21325763 }}</ref> | *May be seen in adults.<ref name=pmid21325763>{{Cite journal | last1 = Hayashi | first1 = H. | last2 = Narita | first2 = R. | last3 = Hiura | first3 = M. | last4 = Abe | first4 = S. | last5 = Tabaru | first5 = A. | last6 = Tanimoto | first6 = A. | last7 = Sasaguri | first7 = Y. | last8 = Harada | first8 = M. | title = A case of adult autoimmune hepatitis with histological features of giant cell hepatitis. | journal = Intern Med | volume = 50 | issue = 4 | pages = 315-9 | month = | year = 2011 | doi = | PMID = 21325763 }}</ref> | ||
*Reported association with [[subdural hematoma]].<ref name=pmid21331818>{{Cite journal | last1 = Guddat | first1 = SS. | last2 = Ehrlich | first2 = E. | last3 = Martin | first3 = H. | last4 = Tsokos | first4 = M. | title = Fatal spontaneous subdural bleeding due to neonatal giant cell hepatitis: a rare differential diagnosis of shaken baby syndrome. | journal = Forensic Sci Med Pathol | volume = 7 | issue = 3 | pages = 294-7 | month = Sep | year = 2011 | doi = 10.1007/s12024-011-9227-8 | PMID = 21331818 }}</ref> | *Reported association with [[subdural hematoma]].<ref name=pmid21331818>{{Cite journal | last1 = Guddat | first1 = SS. | last2 = Ehrlich | first2 = E. | last3 = Martin | first3 = H. | last4 = Tsokos | first4 = M. | title = Fatal spontaneous subdural bleeding due to neonatal giant cell hepatitis: a rare differential diagnosis of shaken baby syndrome. | journal = Forensic Sci Med Pathol | volume = 7 | issue = 3 | pages = 294-7 | month = Sep | year = 2011 | doi = 10.1007/s12024-011-9227-8 | PMID = 21331818 }}</ref> | ||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=pmid20871223>{{Cite journal | last1 = Torbenson | first1 = M. | last2 = Hart | first2 = J. | last3 = Westerhoff | first3 = M. | last4 = Azzam | first4 = RK. | last5 = Elgendi | first5 = A. | last6 = Mziray-Andrew | first6 = HC. | last7 = Kim | first7 = GE. | last8 = Scheimann | first8 = A. | title = Neonatal giant cell hepatitis: histological and etiological findings. | journal = Am J Surg Pathol | volume = 34 | issue = 10 | pages = 1498-503 | month = Oct | year = 2010 | doi = 10.1097/PAS.0b013e3181f069ab | PMID = 20871223 }}</ref> | Features:<ref name=pmid20871223>{{Cite journal | last1 = Torbenson | first1 = M. | last2 = Hart | first2 = J. | last3 = Westerhoff | first3 = M. | last4 = Azzam | first4 = RK. | last5 = Elgendi | first5 = A. | last6 = Mziray-Andrew | first6 = HC. | last7 = Kim | first7 = GE. | last8 = Scheimann | first8 = A. | title = Neonatal giant cell hepatitis: histological and etiological findings. | journal = Am J Surg Pathol | volume = 34 | issue = 10 | pages = 1498-503 | month = Oct | year = 2010 | doi = 10.1097/PAS.0b013e3181f069ab | PMID = 20871223 }}</ref> | ||