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Pediatric gastrointestinal pathology (view source)
Revision as of 04:50, 28 December 2011
, 04:50, 28 December 2011→Giant cell hepatitis: expand, links to images
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==Giant cell hepatitis== | ==Giant cell hepatitis== | ||
*[[AKA]] ''neonatal giant cell hepatitis'', abbreviated ''NGCH''. | |||
===General=== | ===General=== | ||
* | *Rare. | ||
*Etiology unknown - possibly viral, autoimmune and/or drugs.<ref name=pmid21043007>{{Cite journal | last1 = Hartl | first1 = J. | last2 = Buettner | first2 = R. | last3 = Rockmann | first3 = F. | last4 = Farkas | first4 = S. | last5 = Holstege | first5 = A. | last6 = Vogel | first6 = C. | last7 = Schnitzbauer | first7 = A. | last8 = Schlitt | first8 = HJ. | last9 = Schoelmerich | first9 = J. | title = Giant cell hepatitis: an unusual cause of fulminant liver failure. | journal = Z Gastroenterol | volume = 48 | issue = 11 | pages = 1293-6 | month = Nov | year = 2010 | doi = 10.1055/s-0029-1245476 | PMID = 21043007 }}</ref> | |||
* | Notes: | ||
*May be seen in adults.<ref name=pmid21325763>{{Cite journal | last1 = Hayashi | first1 = H. | last2 = Narita | first2 = R. | last3 = Hiura | first3 = M. | last4 = Abe | first4 = S. | last5 = Tabaru | first5 = A. | last6 = Tanimoto | first6 = A. | last7 = Sasaguri | first7 = Y. | last8 = Harada | first8 = M. | title = A case of adult autoimmune hepatitis with histological features of giant cell hepatitis. | journal = Intern Med | volume = 50 | issue = 4 | pages = 315-9 | month = | year = 2011 | doi = | PMID = 21325763 }}</ref> | |||
*Reported association with [[subdural hematoma]].<ref name=pmid21331818>{{Cite journal | last1 = Guddat | first1 = SS. | last2 = Ehrlich | first2 = E. | last3 = Martin | first3 = H. | last4 = Tsokos | first4 = M. | title = Fatal spontaneous subdural bleeding due to neonatal giant cell hepatitis: a rare differential diagnosis of shaken baby syndrome. | journal = Forensic Sci Med Pathol | volume = 7 | issue = 3 | pages = 294-7 | month = Sep | year = 2011 | doi = 10.1007/s12024-011-9227-8 | PMID = 21331818 }}</ref> | *Reported association with [[subdural hematoma]].<ref name=pmid21331818>{{Cite journal | last1 = Guddat | first1 = SS. | last2 = Ehrlich | first2 = E. | last3 = Martin | first3 = H. | last4 = Tsokos | first4 = M. | title = Fatal spontaneous subdural bleeding due to neonatal giant cell hepatitis: a rare differential diagnosis of shaken baby syndrome. | journal = Forensic Sci Med Pathol | volume = 7 | issue = 3 | pages = 294-7 | month = Sep | year = 2011 | doi = 10.1007/s12024-011-9227-8 | PMID = 21331818 }}</ref> | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=pmid20871223>{{Cite journal | last1 = Torbenson | first1 = M. | last2 = Hart | first2 = J. | last3 = Westerhoff | first3 = M. | last4 = Azzam | first4 = RK. | last5 = Elgendi | first5 = A. | last6 = Mziray-Andrew | first6 = HC. | last7 = Kim | first7 = GE. | last8 = Scheimann | first8 = A. | title = Neonatal giant cell hepatitis: histological and etiological findings. | journal = Am J Surg Pathol | volume = 34 | issue = 10 | pages = 1498-503 | month = Oct | year = 2010 | doi = 10.1097/PAS.0b013e3181f069ab | PMID = 20871223 }}</ref> | ||
* | *Giant hepatocytes with multiple nuclei - '''key feature'''. | ||
* | **Typically 35% of hepatocytes affected. | ||
*Minimal or absent inflammation portal and lobular inflammation. | |||
*Lobular cholestasis. | |||
Images: | |||
*[http://www.ikp.unibe.ch/lab2/giant04.jpg GCH (unibe.ch)].<ref>URL: [http://www.ikp.unibe.ch/lab2/labdk.htm http://www.ikp.unibe.ch/lab2/labdk.htm]. Accessed on: 27 December 2011.</ref> | |||
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20090423115718994 GCH (surgicalpathologyatlas.com)]. | |||
=See also= | =See also= | ||