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Difference between revisions of "Invasive breast cancer"
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→Breast IHC: format
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==Breast IHC== | ==Breast IHC== | ||
*DCIS vs LCIS:<ref>{{cite journal |author=Yeh IT, Mies C |title=Application of immunohistochemistry to breast lesions |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=349-58 |year=2008 |month=March |pmid=18318578 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=349}}</ref> | *DCIS vs LCIS:<ref>{{cite journal |author=Yeh IT, Mies C |title=Application of immunohistochemistry to breast lesions |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=349-58 |year=2008 |month=March |pmid=18318578 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=349}}</ref> | ||
**E-cadherin (+ve DCIS, -ve LCIS) | **E-cadherin (+ve DCIS, -ve LCIS). | ||
**antibody 34betaE12 (+ve perinuclear LCIS, -ve DCIS) | **antibody 34betaE12 (+ve perinuclear LCIS, -ve DCIS). | ||
**CAM5.2 (peripheral stain = DCIS, perinuclear stain = LCIS) | **CAM5.2 (peripheral stain = DCIS, perinuclear stain = LCIS). | ||
***CAM5.2 is against CK8 | ***CAM5.2 is against CK8. | ||
** | **Beta-catenin (-LCIS, +DCIS). | ||
*D2-40<ref>{{cite journal |author=Ordóñez NG |title=Podoplanin: a novel diagnostic immunohistochemical marker |journal=Adv Anat Pathol |volume=13 |issue=2 |pages=83-8 |year=2006 |month=March |pmid=16670463 |doi=10.1097/01.pap.0000213007.48479.94 |url=}}</ref><ref>{{cite journal |author=Kahn HJ, Marks A |title=A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors |journal=Lab. Invest. |volume=82 |issue=9 |pages=1255-7 |year=2002 |month=September |pmid=12218087 |doi= |url=}}</ref> | *D2-40:<ref>{{cite journal |author=Ordóñez NG |title=Podoplanin: a novel diagnostic immunohistochemical marker |journal=Adv Anat Pathol |volume=13 |issue=2 |pages=83-8 |year=2006 |month=March |pmid=16670463 |doi=10.1097/01.pap.0000213007.48479.94 |url=}}</ref><ref>{{cite journal |author=Kahn HJ, Marks A |title=A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors |journal=Lab. Invest. |volume=82 |issue=9 |pages=1255-7 |year=2002 |month=September |pmid=12218087 |doi= |url=}}</ref> | ||
** | **Monoclonal antibody to podoplanin. | ||
** | **Useful to assess lymphovascular invasion. | ||
*ADH and DCIS<ref>Lester P.122.</ref> | *ADH and DCIS:<ref>Lester P.122.</ref> | ||
**E-cadherin. | **E-cadherin. | ||
***Present in most epithelial cells. | ***Present in most epithelial cells. | ||