Sclerosing adenosis of the breast
From Libre Pathology
|Sclerosing adenosis of the breast|
|Diagnosis in short|
Sclerosing_adenosis. H&E stain.
|LM||increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini|
|LM DDx||low-grade ductal carcinoma, tubular adenoma of the breast, adenomyoepithelioma, breast adenosis|
|Prognosis||benign, increased risk of breast cancer|
Sclerosing adenosis of the breast, also sclerosing adenosis, a benign pathology of the breast associated with an increased risk of malignancy.
- Can look like ductal carcinoma.
- Derived from sclerosing (hardening) and adenosis (glandular proliferation).
- Think scaring + many glands packed together.
- Follow-up - no further treatment.
- Acini are smaller than usual and there are more of them.
- Acini often slit-like.
- Fibrosis (scleroses) - pink on H&E surrounds the acini.
- Can mimic a desmoplastic reaction.
- The acini should:
- Be in lobular arrangements, i.e. in groups (benign appearance at low power) - key feature.
- Have two cell layers like well-behaved breast glands do.
- Low-grade ductal carcinoma.
- Tubular adenoma of the breast.
- Breast adenosis - should have visble lumens.
- URL: http://dictionary.reference.com/browse/sclerosis. Accessed on: 16 March 2011.
- URL: http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions. Accessed on: 30 April 2012.
- Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.