Sclerosing adenosis of the breast

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Sclerosing adenosis of the breast
Diagnosis in short

Sclerosing_adenosis. H&E stain.

LM increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini
LM DDx low-grade ductal carcinoma, tubular adenoma of the breast, adenomyoepithelioma, breast adenosis
Site breast

Prevalence common
Prognosis benign, increased risk of breast cancer

Sclerosing adenosis of the breast, also sclerosing adenosis, a benign pathology of the breast associated with an increased risk of malignancy.

General

  • Can look like ductal carcinoma.
  • Derived from sclerosing[1] (hardening) and adenosis (glandular proliferation).
    • Think scaring + many glands packed together.

Management:

  • Follow-up - no further treatment.[2]

Microscopic

Features:

  • Acini are smaller than usual and there are more of them.
    • Acini often slit-like.
  • Fibrosis (scleroses) - pink on H&E surrounds the acini.

Notes:

  • The acini should:
    • Be in lobular arrangements, i.e. in groups (benign appearance at low power) - key feature.
    • Have two cell layers like well-behaved breast glands do.

DDx:

Images

See also

References

  1. URL: http://dictionary.reference.com/browse/sclerosis. Accessed on: 16 March 2011.
  2. URL: http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions. Accessed on: 30 April 2012.
  3. Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.