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Diagnosis in short

Adenomyoepithelioma. H&E stain.

LM glandular architecture with: (1) identifiable myoepithelial cells with clear cytoplasm, (2) eosinophilic cuboidal epithelial cells; eosinophilic basement membrane material between glands
LM DDx invasive ductal carcinoma, mammary pleomorphic adenoma, ductal adenoma, tubular adenoma of the breast, sclerosing adenosis
Site breast

Prevalence uncommon
Prognosis benign, occasionally malignant

Adenomyoepithelioma is an uncommon pathology of the breast. It is usually benign.


  • Rare lesion consisting of epithelial and myoepithelial elements.
    • May occur in other sites, e.g. tonsil.[1]
  • May be benign or malignant.[2][3]




  • Well-circumscribed.
  • Glandular architecture with:
    • Easily identifiable myoepithelial cells - with clear cytoplasm - key feature.
    • Eosinophilic cuboidal epithelial cells.
  • Eosinophilic basement membrane material between glands.




See also


  1. Ren, J.; Song, L.; Dang, Q.; Zhang, X.; Jiang, SW.; Zhang, G.; Wang, N.; Liu, Z. et al. (2010). "Primary adenomyoepithelioma of tonsil.". Head Neck Oncol 2: 7. doi:10.1186/1758-3284-2-7. PMID 20356364.
  2. Howlett, DC.; Mason, CH.; Biswas, S.; Sangle, PD.; Rubin, G.; Allan, SM. (Mar 2003). "Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology.". AJR Am J Roentgenol 180 (3): 799-803. PMID 12591699.
  3. Zizi-Sermpetzoglou, A.; Vasilakaki, T.; Grammatoglou, X.; Petrakopoulou, N.; Nikolaidou, ME.; Glava, C. (2009). "Malignant adenomyoepithelioma of the breast--case report.". Eur J Gynaecol Oncol 30 (2): 234-6. PMID 19480267.
  4. Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Arch 433 (3): 285-8. PMID 9769134.
  5. URL: Accessed on: 16 August 2011.
  6. Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: Accessed on: 28 April 2012.