Adenocarcinoma of the rete testis

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Adenocarcinoma of the rete testis
Diagnosis in short

Adenocarcinoma of the rete testis. H&E stain.

LM atypical columnar or cuboidal cells, often with cigar-shaped nuclei; classically tubular or papillary architecture; transistion to normal appearing rete testis
LM DDx adenomatous hyperplasia of the rete testis, Sertoli cell tumour, malignant mesothelioma, metastasis
IHC EMA +ve, CK7 +ve, PSA -ve, calretinin -ve, CK5/6 -ve, PLAP -ve, AFP -ve, CD30 -ve
Gross hilar mass
Grossing notes orchiectomy grossing
Site paratesticular region/testis - see rete testis

Prevalence extremely rare
Blood work markers for GCT typically normal
Prognosis poor
Clin. DDx other testicular mass

Adenocarcinoma of the rete testis, also rete testis adenocarcinoma, is a very rare malignant tumour of the paratesticular region/testis.


  • Extremely rare[1] - a few dozen cases in the world literature.
  • Typically older men (>60 years old), but reported in younger men with undescended testis.[1]
  • Possible association with diethylstilbestrol - based on non-human data.[2]
  • Prognosis poor[3] - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.[4]



  • Lesion of the testicular hilum.[1]



  • Adenocarcinoma:
    • Atypical columnar or cuboidal cells, often with cigar-shaped nuclei.
    • Classically tubular or papillary architecture.[2]
  • Transistion to normal appearing rete testis.[1]







  • AFP -ve.
  • CD30 -ve.
  • PLAP -ve.
  • CK5/6 -ve.
  • Calretinin -ve.
  • PSA -ve.

See also


  1. 1.0 1.1 1.2 1.3 1.4 Nochomovitz, LE.; Orenstein, JM. (Aug 1984). "Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates.". Am J Surg Pathol 8 (8): 625-34. PMID 6465420.
  2. 2.0 2.1 Newbold, RR.; Bullock, BC.; McLachlan, JA. (Dec 1986). "Adenocarcinoma of the rete testis. Diethylstilbestrol-induced lesions of the mouse rete testis.". Am J Pathol 125 (3): 625-8. PMC 1888460. PMID 3799821. //
  3. Sogni, F.; Monga, G.; Terrone, C.; Gontero, P. (2008). "Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas.". Scand J Urol Nephrol 42 (1): 83-5. doi:10.1080/00365590701517608. PMID 17853037.
  4. Sánchez-Chapado, M.; Angulo, JC.; Haas, GP. (Oct 1995). "Adenocarcinoma of the rete testis.". Urology 46 (4): 468-75. doi:10.1016/S0090-4295(99)80257-X. PMID 7571213.
  5. 5.0 5.1 5.2 Lin, XY.; Yu, JH.; Xu, HT.; Wang, L.; Fan, CF.; Liu, Y.; Wang, EH. (2013). "A case of adenocarcinoma of the rete testis accompanied by focal adenomatous hyperplasia.". Diagn Pathol 8: 105. doi:10.1186/1746-1596-8-105. PMID 23800084.
  6. Ulbright, TM.; Young, RH. (Nov 2008). "Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features.". Am J Surg Pathol 32 (11): 1683-93. doi:10.1097/PAS.0b013e3181788516. PMID 18769334.
  7. Yang, Z.; Sheng, C.; Cao, L.; Wang, D.. "Adenocarcinoma of rete testis with widespread liver metastasis.". Can Urol Assoc J 7 (9-10): E654-6. doi:10.5489/cuaj.470. PMID 24409217.
  8. Tian, Y.; Yao, W.; Yang, L.; Wang, J.; Wazir, R.; Wang, K. (Feb 2014). "Primary adenocarcinoma of the rete testis: A case report and review of the literature.". Oncol Lett 7 (2): 455-457. doi:10.3892/ol.2013.1708. PMID 24396468.
  9. Wu, CA.; Chen, YH.; Man, KM.; Shen, JL.; Chen, WC. (2011). "Papillary adenocarcinoma of rete testis mimics inflammatory lump: a case report.". Case Rep Urol 2011: 857812. doi:10.1155/2011/857812. PMID 22606627.