Malignant histiocytosis
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Malignant histiocytosis is a rare malignant type of histiocytosis.
Histiocytic sarcoma is considered by many as a synonym;[1] it redirects to this article.
General
- Uncommon.
Microscopic
Features:[2]
- Malignant histiocyte-like cells:
- Nuclear atypia.
- Abundant eosinophilic cytoplasm.
DDx:
- Pleomorphic undifferentiated sarcoma.
- Poorly differentiated carcinoma.
Image:
IHC
Features:[2]
- CD68 +ve.
See also
- Histiocytoses.
- Classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.
- Sarcoma.
References
- ↑ Low, SE.; Stafford, JS. (Jul 2006). "Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture.". J Clin Pathol 59 (7): 770-2. doi:10.1136/jcp.2005.027870. PMID 16803951.
- ↑ 2.0 2.1 Alexiev, BA.; Sailey, CJ.; McClure, SA.; Ord, RA.; Zhao, XF.; Papadimitriou, JC. (2007). "Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component.". Diagn Pathol 2: 7. doi:10.1186/1746-1596-2-7. PMC 1808440. PMID 17324277. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/.