Classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages
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Classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages is an evolving classification published by the Histiocyte Society.
The version published in 2016 consists of five groups:[1]
| Group | Diseases | Details |
|---|---|---|
| L group | Langerhans cell histiocytosis (LCH), indeterminate cell histiocytosis, Erdheim-Chester disease (ECD), mixed LCH/ECD | |
| C group | cutaneous non-LCH, cutaneous non-LCH with major systemic component | cutaneous non-LCH subdivided into: XG family JXG, non-XG family |
| R group | familial Rosai-Dorfman disease (RDD), sporadic RDD | sporadic RCC includes: classical RDD, extra-nodal RDD, RDD with neoplasia or autoimmune disease, unclassified RDD |
| M group | primary malignant histiocytoses, secondary malignant histiocytoses | secondary malignant histiocytosis follow another hematologic malignancy; subclassified as: histiocytic, interdigitating, Langerhans, indeterminate cell |
| H group | primary hemophagocytic lymphohistiocytosis (HLH), secondary hemophagocytic lymphohistiocytosis, HLH or unknown/uncertain origin | secondary HLH is non-Mendelian |
Lame way to remember the groupings: Malignant Histiocytoses Can Result in Lifelessness.
See also
References
- ↑ Emile, JF.; Abla, O.; Fraitag, S.; Horne, A.; Haroche, J.; Donadieu, J.; Requena-Caballero, L.; Jordan, MB. et al. (06 2016). "Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.". Blood 127 (22): 2672-81. doi:10.1182/blood-2016-01-690636. PMID 26966089.