Multiple endocrine neoplasia

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C-cell hyperplasia, as may be seen in the context of MEN 2A or MEN 2B. H&E stain.

Multiple endocrine neoplasia, abbreviated MEN, refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

Simple

MEN 1

Memory device: 3 Ps.

Note:
‡ May be mislabeled as parathyroid hyperplasia.[2]

MEN 2A (II)

Notes - memory device:

  • Both MEN 1 and MEN 2A have parathyroid adenomas.
  • Each has additional neoplasms below and above the diaphragm.

MEN 2B (III)

Details

MEN 1

Gene:

Characteristics:[3]

MEN 2A

Gene:

Characteristics:[3]

  • Medullary thyroid carcinoma - in almost 100%.

Treatment:

  • Patients are advised to have prophylactic thyroidectomy.

Images:

Trivia:

MEN 2B

Gene:

Characteristics:

Treatment:

  • Patients are advised to have prophylactic thyroidectomy.

References

  1. 1.0 1.1 Online 'Mendelian Inheritance in Man' (OMIM) 131100
  2. Doherty GM, Lairmore TC, DeBenedetti MK (November 2004). "Multiple endocrine neoplasia type 1 parathyroid adenoma development over time". World J Surg 28 (11): 1139–42. doi:10.1007/s00268-004-7560-8. PMID 15490065.
  3. 3.0 3.1 3.2 3.3 3.4 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1162. ISBN 978-1416031215. }}
  4. Zollinger RM, Ellison EH (1955). "Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas". Ann. Surg. 142 (4): 709–23; discussion, 724–8. doi:10.1097/00000658-195510000-00015. PMC 1465210. PMID 13259432. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/.
  5. Davies, SJ.; Gosney, JR.; Hansell, DM.; Wells, AU.; du Bois, RM.; Burke, MM.; Sheppard, MN.; Nicholson, AG. (Mar 2007). "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.". Thorax 62 (3): 248-52. doi:10.1136/thx.2006.063065. PMID 17099078.
  6. Online 'Mendelian Inheritance in Man' (OMIM) 171400
  7. 7.0 7.1 Online 'Mendelian Inheritance in Man' (OMIM) 162300
  8. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1160. ISBN 978-1416031215.
  9. Haraguchi M, Kinoshita H, Koori M, et al. (2007). "Multiple rectal carcinoids with diffuse ganglioneuromatosis". World J Surg Oncol 5: 19. doi:10.1186/1477-7819-5-19. PMC 1805501. PMID 17306015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805501/.
  10. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 215. ISBN 978-0443066573.