Ganglioneuroma

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Ganglioneuroma
Diagnosis in short

Adrenal Ganglioneuroma. H&E stain.

LM ganglion cells (large cells with large nucleus and prominent nucleolus), disordered fibrinous-like material, eosinophilic granular bodies
LM DDx ganglioneuroblastoma
IHC synaptophysin +ve, S-100 +ve
Gross solid, firm, white
Site usually adrenal or retroperitoneal, paraspinal

Prevalence uncommon
Prognosis good

Ganglioneuroma is a benign neuroblasic tumour. It is also known as ganglioma.[1]

It should not to be confused with ganglioglioma.

General

Classification:

Gross

  • Solid.
  • White.
  • Firm.
  • Well-circumscribed.
  • May be nodular.

Images

www:

Microscopic

Features:

  • Ganglion cells - key feature.
    • Large cells with large nucleus.
      • Prominent nucleolus.
  • Disordered fibrinous-like material.
  • Eosinophilic granular bodies.[3]

See: adrenal ganglioneuroma, colonic ganglioneuroma.

Images

www:

IHC

Features:[4]

  • Spindle cells: S-100 +ve.
  • Ganglion cells: NSE, synaptophysin, NF.

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Paraspinal Lesion, Right, Core Biopsy:
- Ganglioneuroma.

Comment:
The lesion stains as follows:
POSITIVE: S-100 & vimentin (stroma, ganglion cells), synaptophysin (ganglion cells only).
NEGATIVE: AE1/AE3, CD34.
PROLIFERATION (Ki-67): <1% of cells.

See also

References

  1. URL: http://medical-dictionary.thefreedictionary.com/ganglioma. Accessed on: 8 November 2010.
  2. Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B (July 1999). "Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee". Cancer 86 (2): 349–63. PMID 10421272.
  3. R. Kiehl. 8 November 2010.
  4. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 217. ISBN 978-0443066573.