Invasive cribriform carcinoma of the breast

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Invasive cribriform carcinoma of the breast
Diagnosis in short

Invasive cribriform carcinoma of the breast. H&E stain.
LM cribriform architecture, stromal desmoplasia, +/-tubular component
LM DDx tubular carcinoma, cribriform DCIS, mixed tumour (e.g. ICC with IDC), adenoid cystic carcinoma of the breast
IHC ER +ve, PR +ve, HER2 -ve
Site breast
Prevalence very rare
Prognosis good
Treatment surgical

Invasive cribriform carcinoma of the breast is a rare type of breast cancer with a favourable prognosis.[1]

General

  • Rare ~ 0.6% of breast cancer in one series.[2]
  • Low grade.
  • Good prognosis if pure or associated with a tubular invasive component.[3]

Microscopic

Features:[4]

Notes:

  • Cribriform component should be >90% of the tumour.[4]
  • Low or intermediate Nottingham grade.

DDx:

Images

  • Breast invasive cribriform carcinoma - low power. (SKB)

  • Breast invasive cribriform carcinoma - medium power. (SKB)

  • Breast invasive cribriform carcinoma - high power. (SKB)

www:

IHC

Features:[1]

  • ER +ve (9 +ve of 9 cases).
  • PR +ve (9 +ve of 9 cases).
  • HER2 -ve (0 +ve of 9 cases).

See also

References

  1. ↑ 1.0 1.1 Cong, Y.; Qiao, G.; Zou, H.; Lin, J.; Wang, X.; Li, X.; Li, Y.; Zhu, S. (Apr 2015). "Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature.". Oncol Lett 9 (4): 1753-1758. doi:10.3892/ol.2015.2972. PMID 25789036.
  2. ↑ Stutz, JA.; Evans, AJ.; Pinder, S.; Ellis, IO.; Yeoman, LJ.; Wilson, AR.; Sibbering, DM. (Oct 1994). "The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team.". Clin Radiol 49 (10): 693-5. PMID 7955831.
  3. ↑ Page, DL.; Dixon, JM.; Anderson, TJ.; Lee, D.; Stewart, HJ. (Jul 1983). "Invasive cribriform carcinoma of the breast.". Histopathology 7 (4): 525-36. PMID 6884999.
  4. ↑ 4.0 4.1 4.2 Zhang, W.; Zhang, T.; Lin, Z.; Zhang, X.; Liu, F.; Wang, Y.; Liu, H.; Yang, Y. et al. (2013). "Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified.". Int J Clin Exp Pathol 6 (3): 445-57. PMC 3563205. PMID 23412348. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563205/.
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