Foamy gland carcinoma

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Foamy gland carcinoma
Diagnosis in short

Foamy gland carcinoma. H&E stain.

Synonyms foamy gland adenocarcinoma
Subtypes (subtype of prostate carcinoma)
LM DDx adenosis of the prostate, bulbourethral gland, pseudohyperplastic adenocarcinoma
IHC AMACR +ve, CK5/6 -ve, p63 -ve
Gross see prostate carcinoma
Grossing notes see prostate carcinoma
Staging prostate cancer staging
Site prostate gland - see prostate carcinoma

Syndromes see prostate carcinoma

Prevalence uncommon
Prognosis often good, dependent on grade & stage
Clin. DDx see prostate carcinoma
Treatment see prostate carcinoma

Foamy gland carcinoma, also foamy gland adenocarcinoma,[1] is an uncommon variant of prostate carcinoma that has a bland appearance and may be confused with benign glands.




  • Increased glandular density - key feature.
  • Eosinophilic intraluminal amorphous secretions - key feature.
  • Abundant foamy cytoplasm.
  • Tufted glandular border.
  • Gland size larger than "typical" prostate cancer.





See also


  1. 1.0 1.1 1.2 Zhao, J.; Epstein, JI. (Apr 2009). "High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases.". Am J Surg Pathol 33 (4): 583-90. doi:10.1097/PAS.0b013e31818a5c6c. PMID 19033862.