Pseudohyperplastic prostatic adenocarcinoma

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Pseudohyperplastic prostatic adenocarcinoma
Diagnosis in short

Pseudohyperplastic carcinoma. H&E stain.

LM medium to large glands with an atypical morphology (papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation), nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement)
Subtypes subtype of prostate carcinoma
LM DDx benign prostatic tissue, foamy gland carcinoma
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Staging prostate cancer staging
Site prostate gland - see prostate carcinoma

Prevalence uncommon
Blood work +/-PSA elevated
Treatment see prostate carcinoma

Pseudohyperplastic prostatic adenocarcinoma, also pseudohyperplastic adenocarcinoma is an uncommon type of prostate carcinoma that may mimic benign prostate.

General

  • Uncommon <3% of cases in one series.[1]
  • May mimic benign prostate.[1]
  • Can be found with or without conventional prostatic adenocarcinoma (acinar type).

Microscopic

Features:[2][1]

  • Medium to large glands with an atypical morphology - key low power feature:
    • Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation.
  • Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).

Notes:

  • Often associated with conventional (acinar) prostate adenocarcinoma.
  • Pale abundant cytoplasm - similar to normal prostate.

DDx:

  • Foamy gland carcinoma - often lack prominent nucleoli, smaller glands.
  • Benign prostatic glands - esp. at low power.

Images

www:

See also

References

  1. 1.0 1.1 1.2 Arista-Nasr J, Martinez-Benitez B, Valdes S, Hernández M, Bornstein-Quevedo L (2003). "Pseudohyperplastic prostatic adenocarcinoma in transurethral resections of the prostate". Pathol. Oncol. Res. 9 (4): 232–5. doi:PAOR.2003.9.4.0232. PMID 14688829.
  2. Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 77. ISBN 978-0443066771.