Well-differentiated papillary mesothelioma
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| Well-differentiated papillary mesothelioma | |
|---|---|
| Diagnosis in short | |
 Well-differentiated papillary mesothelioma. H&E stain. | |
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| Synonyms | benign papillary mesothelioma |
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| LM | papillary structures with thick fibrous cores and simple cuboidal epithelium, lacks cytologic atypia |
| LM DDx | ovarian serous carcinoma, serous borderline tumour of the ovary, malignant mesothelioma |
| IHC | calretinin +ve, CK5/6 +ve |
| Site | pleura, peritoneum, tunica vaginalis (testis) |
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| |
| Prevalence | rare |
| Prognosis | typically indolent |
| Clin. DDx | tuberculosis, carcinomatosis, primary peritoneal serous carcinoma, others |
Well-differentiated papillary mesothelioma, abbreviated WDPM, is a rare type of mesothelioma that typically has an indolent behaviour.[1]
It is also known as benign papillary mesothelioma. It should not be confused with malignant mesothelioma and benign multicystic mesothelioma.
General
- Benign.
- Some say it is borderline.[2]
- Classically women of reproductive age.[3]
- Reported in tunica vaginalis of the testis.[4]
- Associated with asbestos exposure.[1]
Gross
Typical features for peritoneum:
- Multiple peritoneal nodules.
- Ascites.
DDx (peritoneum):[3]
- Tuberculosis.
- Carcinomatosis.
- Primary peritoneal serous carcinoma.
Microscopic
Features:
- Papillary structures with:
- Thick fibrous cores.
- Simple cuboidal epithelium.
- Small nucleoli.
Note:
- Lack cytologic atypia.
DDx:[5]
Images
WDPM - low mag.
WDPM - intermed. mag.
WDPM - high mag.
WDPM - very high mag.
WDPM - low mag.
WDPM - intermed. mag.
WDPM - high mag.
www:
IHC
Features:[6]
- Calretinin +ve.
- CK5/6 +ve.
See also
References
- ↑ 1.0 1.1 Butnor, KJ.; Sporn, TA.; Hammar, SP.; Roggli, VL. (Oct 2001). "Well-differentiated papillary mesothelioma.". Am J Surg Pathol 25 (10): 1304-9. PMID 11688466.
- ↑ Bürrig, KF.; Pfitzer, P.; Hort, W. (1990). "Well-differentiated papillary mesothelioma of the peritoneum: a borderline mesothelioma. Report of two cases and review of literature.". Virchows Arch A Pathol Anat Histopathol 417 (5): 443-7. PMID 2122588.
- ↑ 3.0 3.1 Park, JY.; Kim, KW.; Kwon, HJ.; Park, MS.; Kwon, GY.; Jun, SY.; Yu, ES. (Sep 2008). "Peritoneal mesotheliomas: clinicopathologic features, CT findings, and differential diagnosis.". AJR Am J Roentgenol 191 (3): 814-25. doi:10.2214/AJR.07.3628. PMID 18716115.
- ↑ Chetty, R. (Nov 1992). "Well differentiated (benign) papillary mesothelioma of the tunica vaginalis.". J Clin Pathol 45 (11): 1029-30. PMID 1452778.
- ↑ Truong, LD.; Maccato, ML.; Awalt, H.; Cagle, PT.; Schwartz, MR.; Kaplan, AL. (Jan 1990). "Serous surface carcinoma of the peritoneum: a clinicopathologic study of 22 cases.". Hum Pathol 21 (1): 99-110. PMID 1688545.
- ↑ Malpica, A.; Sant'Ambrogio, S.; Deavers, MT.; Silva, EG. (Jan 2012). "Well-differentiated papillary mesothelioma of the female peritoneum: a clinicopathologic study of 26 cases.". Am J Surg Pathol 36 (1): 117-27. doi:10.1097/PAS.0b013e3182354a79. PMID 22024662.