Serous borderline tumour

From Libre Pathology
Jump to navigation Jump to search
Serous borderline tumour
Diagnosis in short

Serous borderline tumour with a micropapillary pattern. H&E stain.

LM cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-psammoma bodies, +/-micropapillary architecture (often described as a medusa head pattern)
Subtypes serous borderline tumour (SBT) with micropapillary pattern, typical SBT or SBT not otherwise specified
LM DDx serous cystadenoma, serous carcinoma of the ovary, clear cell carcinoma of the ovary
Site ovary, uterine tube - see ovarian tumours

Prevalence uncommon
Prognosis usually benign, need follow-up
Clin. DDx other ovarian tumours (benign and malignant)
Treatment excision, follow-up

Serous borderline tumour is a Muellerian epithelial ovarian tumour with a behaviour that borders on malignant.

It is also known as serous tumour of low malignant potential, abbreviated SLMP.[1][2]

Serous ovarian tumour of low malignant potential redirects here.[2]


  • Usually benign.
  • Require long term follow-up.



  • Cuboidal to columnar epithelium with mild to moderate atypia.
  • Non-invasive.
  • "Sparse" mitoses.
  • +/-Psammoma bodies.
  • +/-Micropapillary architecture - often described as a medusa head pattern.





Typical subdivided into:[5]

  • Micropapillary serous borderline tumour.
  • Typical serous borderline tumour (SBOT).

Sign out

Cyst and Right Fallopian Tube, Excision:
- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
- Fallopian tube within normal limits.
- NEGATIVE for evidence of invasion.

The lesion appears to be confined to a cystic structure.

See also


  1. Seidman, JD.; Kurman, RJ. (May 2000). "Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.". Hum Pathol 31 (5): 539-57. PMID 10836293.
  2. 2.0 2.1 Dietel, M.; Hauptmann, S. (May 2000). "Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology.". Virchows Arch 436 (5): 403-12. PMID 10881733.
  3. 3.0 3.1 3.2 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 399. ISBN 978-0443069208.
  4. Burkholz, KJ.; Wood, BP.; Zuppan, C.. "Best cases from the AFIP: Borderline papillary serous tumor of the right ovary.". Radiographics 25 (6): 1689-92. doi:10.1148/rg.256055015. PMID 16284143.
  5. Park, JY.; Kim, DY.; Kim, JH.; Kim, YM.; Kim, KR.; Kim, YT.; Nam, JH. (Dec 2011). "Micropapillary pattern in serous borderline ovarian tumors: does it matter?". Gynecol Oncol 123 (3): 511-6. doi:10.1016/j.ygyno.2011.08.008. PMID 21917305.