Worst pattern of invasion

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Worst pattern of invasion, abbreviated WPOI, is schema for classifying tumour morphologic patterns with the goal of predicting tumour behaviour.[1]

General

  • WPOI is predictive of disease free survival in oral cancer.[1]

WPOI is described as five patterns - but generally divided into two (prognostic) groups:

  • WPOI 1-4: better prognosis.
  • WPOI 5: poor prognosis.

Definition of WPOI 5

WPOI 5 is defined as >=1 mm normal tissue between two tumour masses.[2]

See also

References

  1. 1.0 1.1 Shimizu S, Miyazaki A, Sonoda T, Koike K, Ogi K, Kobayashi JI, Kaneko T, Igarashi T, Ueda M, Dehari H, Miyakawa A, Hasegawa T, Hiratsuka H (2018). "Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion". PLoS One 13 (4): e0195451. doi:10.1371/journal.pone.0195451. PMC 5909609. PMID 29672550. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909609/.
  2. Sinha N, Rigby MH, McNeil ML, Taylor SM, Trites JR, Hart RD, Bullock MJ (May 2018). "The histologic risk model is a useful and inexpensive tool to assess risk of recurrence and death in stage I or II squamous cell carcinoma of tongue and floor of mouth". Mod Pathol 31 (5): 772–779. doi:10.1038/modpathol.2017.183. PMID 29393297.