Difference between revisions of "Uterine carcinosarcoma"

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==General==
==General==
* Associated with previous radiation exposure.
* Associated with previous radiation exposure.
* Metstasize as [[adenocarcinoma]].
* Typically metstasize as [[carcinoma]].<ref name=pmid21309261>{{Cite journal  | last1 = Lopez-Garcia | first1 = MA. | last2 = Palacios | first2 = J. | title = Pathologic and molecular features of uterine carcinosarcomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 274-86 | month = Nov | year = 2010 | doi =  | PMID = 21309261 }}</ref>
* Aggressive/poor prognosis;<ref name=pmid15688674>{{Cite journal  | last1 = Ivy | first1 = JJ. | last2 = Unger | first2 = JB. | title = Malignant mixed mullerian sarcomas of the uterus--the LSUHSC Shreveport experience. | journal = J La State Med Soc | volume = 156 | issue = 6 | pages = 324-6 | month =  | year =  | doi =  | PMID = 15688674 }}</ref> in one series 5 year survival ~= 30-35%.<ref name=pmid14967435>{{Cite journal  | last1 = Callister | first1 = M. | last2 = Ramondetta | first2 = LM. | last3 = Jhingran | first3 = A. | last4 = Burke | first4 = TW. | last5 = Eifel | first5 = PJ. | title = Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. | journal = Int J Radiat Oncol Biol Phys | volume = 58 | issue = 3 | pages = 786-96 | month = Mar | year = 2004 | doi = 10.1016/S0360-3016(03)01561-X | PMID = 14967435 }}</ref>
* Aggressive/poor prognosis;<ref name=pmid15688674>{{Cite journal  | last1 = Ivy | first1 = JJ. | last2 = Unger | first2 = JB. | title = Malignant mixed mullerian sarcomas of the uterus--the LSUHSC Shreveport experience. | journal = J La State Med Soc | volume = 156 | issue = 6 | pages = 324-6 | month =  | year =  | doi =  | PMID = 15688674 }}</ref> in one series 5 year survival ~= 30-35%.<ref name=pmid14967435>{{Cite journal  | last1 = Callister | first1 = M. | last2 = Ramondetta | first2 = LM. | last3 = Jhingran | first3 = A. | last4 = Burke | first4 = TW. | last5 = Eifel | first5 = PJ. | title = Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. | journal = Int J Radiat Oncol Biol Phys | volume = 58 | issue = 3 | pages = 786-96 | month = Mar | year = 2004 | doi = 10.1016/S0360-3016(03)01561-X | PMID = 14967435 }}</ref>
*Considered to be a poorly differentiated [[endometrial carcinoma]] with metaplastic changes.<ref name=pmid19853898>{{Cite journal  | last1 = D'Angelo | first1 = E. | last2 = Prat | first2 = J. | title = Uterine sarcomas: a review. | journal = Gynecol Oncol | volume = 116 | issue = 1 | pages = 131-9 | month = Jan | year = 2010 | doi = 10.1016/j.ygyno.2009.09.023 | PMID = 19853898 }}</ref>
*Considered to be a poorly differentiated [[endometrial carcinoma]] with metaplastic changes.<ref name=pmid19853898>{{Cite journal  | last1 = D'Angelo | first1 = E. | last2 = Prat | first2 = J. | title = Uterine sarcomas: a review. | journal = Gynecol Oncol | volume = 116 | issue = 1 | pages = 131-9 | month = Jan | year = 2010 | doi = 10.1016/j.ygyno.2009.09.023 | PMID = 19853898 }}</ref>

Revision as of 21:51, 17 July 2015

Uterine carcinosarcoma
Diagnosis in short

Carcinosarcoma. H&E stain.

LM biphasic tumour: (1) malignant epithelial component (carcinoma), (2) mesenchymal differentiation ("sarcoma")
LM DDx undifferentiated endometrial sarcoma, adenosarcoma of the uterus, endometrial carcinomas
Site uterus - see uterine tumours

Clinical history +/-previous radiation exposure
Prevalence uncommon
Prognosis poor

Uterine carcinosarcoma, also known as malignant mixed muellerian tumour (abbreviated MMMT), is an uncommon malignant uterine tumour.

General

Microscopic

Features:[5]

DDx:

Images

www:

See also

References

  1. Lopez-Garcia, MA.; Palacios, J. (Nov 2010). "Pathologic and molecular features of uterine carcinosarcomas.". Semin Diagn Pathol 27 (4): 274-86. PMID 21309261.
  2. Ivy, JJ.; Unger, JB.. "Malignant mixed mullerian sarcomas of the uterus--the LSUHSC Shreveport experience.". J La State Med Soc 156 (6): 324-6. PMID 15688674.
  3. Callister, M.; Ramondetta, LM.; Jhingran, A.; Burke, TW.; Eifel, PJ. (Mar 2004). "Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome.". Int J Radiat Oncol Biol Phys 58 (3): 786-96. doi:10.1016/S0360-3016(03)01561-X. PMID 14967435.
  4. D'Angelo, E.; Prat, J. (Jan 2010). "Uterine sarcomas: a review.". Gynecol Oncol 116 (1): 131-9. doi:10.1016/j.ygyno.2009.09.023. PMID 19853898.
  5. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 428. ISBN 978-0781765275.