Difference between revisions of "Tumour budding"

From Libre Pathology
Jump to navigation Jump to search
(→‎Sign out: fix typo)
 
(2 intermediate revisions by the same user not shown)
Line 18: Line 18:
**Microscopes with a 22 mm eye pieces typically have a 0.2376 mm*mm field area with the 40x objective; thus, three fields is 0.7128 mm*mm.
**Microscopes with a 22 mm eye pieces typically have a 0.2376 mm*mm field area with the 40x objective; thus, three fields is 0.7128 mm*mm.
**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal  | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi =  | PMID = 11952856 }}</ref>
**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal  | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi =  | PMID = 11952856 }}</ref>
*"Tumour buds suspended in pools of mucin should not be counted" as per the consensus.<ref name=pmid28548122/>


DDx:
DDx:
Line 48: Line 49:
*[[In-transit metastasis]].
*[[In-transit metastasis]].
*[[Tumour deposits]].
*[[Tumour deposits]].
*[[Worst pattern of invasion]].
*[[Spread through air spaces]].


==References==
==References==

Latest revision as of 15:50, 25 August 2023

Tumour budding in colorectal carcinoma. H&E stain. (WC/Nephron)

Tumour budding refers to lone tumour cells or small clusters of tumour cells at the advancing front of a tumour.[1]

General

Microscopic

Definition in rectal carcinoma - based on international consensus:[4]

  • Tumour bud = 1-4 cell(s) -- at the tumour front.

Grading:

  • Low grade: 0-4 tumour buds.
  • Intermediate grade: 5-9 tumour buds.
  • High grade: >=10 tumour buds.

Note:

  • Assessed in a field area of 0.785 mm2.[4]
    • Microscopes with a 22 mm eye pieces typically have a 0.2376 mm*mm field area with the 40x objective; thus, three fields is 0.7128 mm*mm.
    • Tumour budding was previously assessed in a field of 0.385 mm2.[1]
  • "Tumour buds suspended in pools of mucin should not be counted" as per the consensus.[4]

DDx:

Images

Sign out

There are <5 tumour buds/0.785 mm*mm; this tumour has low grade tumour budding.
There are 5-9 tumour buds/0.785 mm*mm; this tumour has intermediate grade tumour budding.
There are >=10 tumour buds/0.785 mm*mm; this tumour has high grade tumour budding.

Alternate

The tumour is NEGATIVE for significant tumour budding (<5 buds/0.785 mm*mm).

See also

References

  1. 1.0 1.1 Ueno, H.; Murphy, J.; Jass, JR.; Mochizuki, H.; Talbot, IC. (Feb 2002). "Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer.". Histopathology 40 (2): 127-32. PMID 11952856.
  2. Mitrovic, B.; Schaeffer, DF.; Riddell, RH.; Kirsch, R. (Oct 2012). "Tumor budding in colorectal carcinoma: time to take notice.". Mod Pathol 25 (10): 1315-25. doi:10.1038/modpathol.2012.94. PMID 22790014.
  3. Gujam, FJ.; McMillan, DC.; Mohammed, ZM.; Edwards, J.; Going, JJ. (Sep 2015). "The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer.". Br J Cancer 113 (7): 1066-74. doi:10.1038/bjc.2015.287. PMID 26263482.
  4. 4.0 4.1 4.2 Lugli, A.; Kirsch, R.; Ajioka, Y.; Bosman, F.; Cathomas, G.; Dawson, H.; El Zimaity, H.; Fléjou, JF. et al. (Sep 2017). "Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.". Mod Pathol 30 (9): 1299-1311. doi:10.1038/modpathol.2017.46. PMID 28548122.