Tumour-infiltrating lymphocytes

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Tumour-infiltrating lymphocytes, abbreviated TILs, is the presence of many lymphoctyes between tumour cells.

Tumour-infiltrating lymphocytes. H&E stain.

TILs in the context of colorectal carcinoma are dealt with in intratumoural lymphocytic response in colorectal carcinoma.

General

Common finding in a large number of tumours:

Tumour Association
Colorectal carcinoma TILs associated with microsatellite instability[1]
Malignant melanoma TILs better survivall[2]
Non-small cell lung cancer TILs associated with anti-PD-L1 response[3]
Ovarian serous carcinoma TILs associated with good prognosis[4]

See also

References

  1. Iacopetta, B.; Grieu, F.; Amanuel, B. (Dec 2010). "Microsatellite instability in colorectal cancer.". Asia Pac J Clin Oncol 6 (4): 260-9. doi:10.1111/j.1743-7563.2010.01335.x. PMID 21114775.
  2. Lee, N.; Zakka, LR.; Mihm, MC.; Schatton, T. (Feb 2016). "Tumour-infiltrating lymphocytes in melanoma prognosis and cancer immunotherapy.". Pathology 48 (2): 177-87. doi:10.1016/j.pathol.2015.12.006. PMID 27020390.
  3. Fehrenbacher, L.; Spira, A.; Ballinger, M.; Kowanetz, M.; Vansteenkiste, J.; Mazieres, J.; Park, K.; Smith, D. et al. (Mar 2016). "Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial.". Lancet. doi:10.1016/S0140-6736(16)00587-0. PMID 26970723.
  4. Webb, JR.; Milne, K.; Kroeger, DR.; Nelson, BH. (May 2016). "PD-L1 expression is associated with tumor-infiltrating T cells and favorable prognosis in high-grade serous ovarian cancer.". Gynecol Oncol 141 (2): 293-302. doi:10.1016/j.ygyno.2016.03.008. PMID 26972336.