Difference between revisions of "Short answer questions submitted by Tate"

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== [[Molecular Genetic Diagnosis]]==
== [[Molecular Genetic Diagnosis]]==


==[[CAP Molecular Diagnosis of Lung Cancer]]==
==[[CAP Molecular Diagnosis of Lung Cancer]]==
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==[[CAP Molecular Diagnosis of AML]]==
==[[CAP Molecular Diagnosis of AML]]==


=== CAP Breast Cancer and Molecular ===
==[[CAP Breast Cancer and Molecular]]==
 
{{Hidden|List 3 patient and 4 tumour features that affect Prognosis and treatment.|Patient: age, menstual status, comorbidities; Tumour factors: N status, LVI, size, grade}}
 
{{hidden|Describe the histological grading system used for breast cancer.|Nuclear pleomorphism, mitoses, and mitotic index (each scored 1-3), with cumulative grade 1(score 3-5), grade 2(score 6-7), and grade 3 (score 8-9)}}
 
{{hidden|Describe the genomic grading system used for breast cancer.|Low grade path (+1q, -16q), High grade (17q12, 11q13, nad 1p21-p25)}}
 
{{hidden|What defines a positive ER by IHC for the purpose of determining Tamoxifen therapy?|>=1% of invasive tumour cells nuclear positivity}}
 
{{hidden|what defines a positive HER2 for the purpose of treatment with Herceptin?|HER2 IHC >30% with complete membranous staining OR HER2/CEP17 >2.2}}
 
{{hidden|What are the indications for chemotherapy for breast cancer patients?|Low expression of ER/PR, Grade 3 histology, Ki67>20%, 4+ nodes positive, +LVI, and tumour >5cm]}}
 
{{hidden|What are the indications for hormonal therapy alone?|high expression of ER, Grade 1, Ki67>40%, Node negative, LVI not identified, and tumour 1-2cm}}
 
{{hidden|What are the four categories of breast cancer using the molecular classification of gene expression?|Luminal A, Luminal B, Basal, and Her2 OverExpression}}
 
{{hidden|What is the difference between unsupervised and supervised molecular classification of tumours?|Supervised is based on seperating patients by clinical features (e.g. progression) and trying to identify common molecular characteristics within those groups. Unsupervised is the opposite, tumours are grouped by common molecular features and their behaviour examined based on these groups.}}
 
{{hidden|What are the four groups and list one gene for each used in the Oncotype Dx 21 Gene prognostic model.|Invasion (Cathespin L2, Stromolysin), HER2 (Her2, GRB7), ER (BCL2, SCUBE2, ER, PR), Proliferation (Cyclin D1, Ki67, MYBL2, STK15, Survivin)}}
 
{{hidden|What are the features of Luminal A breast cancer?|High ER/PR expression, low histological grade, low levels of proliferative genes, HER2neg, indolent clinical course, better prognosis, Tamoxifen responders, low recurrence score Oncotype Dx, minimal benefits of adjuvant chemotherapy.}}
 
{{hidden|What are the features of Luminal B breast cancer?|low ER/PR expression (may be PR neg), over expression GFR(Her2 & EGFR), higher histological grade, more aggressive clinical course, worse prognosis, more likely positive lymph nodes, and high expression of proliferative genes (Ki67)}}
 
{{hidden|What are the features of Luminal B HER2| ER+, HER2+, agressive clinical course, decrease response to tamoxifen, may benefit from chemo and tamoxifen, increased recurrence risk Oncotype Dx Score, some may benefit form Herceptin+Chemo+Tamoxifen}}
 
{{hidden|What are the features of Her2 Enriched breast cancers?| GEP are ER neg, over expression of other genes in HER2 aplification, high proliferative index, increased probability of P53 mutation, high histological grade, younger age, agressive clinical course, Poor Px, good response to herceptin in combination with chemo, pathological complete response to chemo+herceptin}}
 
 
{{hidden|What are the features of Basal breast cancer?|}}

Revision as of 13:28, 12 August 2015

Short answer questions on genetics and molecular pathology.

These are some questions I came up with that are plausible to me... let me know if they are out to lunch.

Molecular Pathology Rotation Notes

Robbins and Cotran 9th Edition Questions

Cytogenetics Review Questions

Molecular Genetic Diagnosis

CAP Molecular Diagnosis of Lung Cancer

CAP Molecular Diagnosis of AML

CAP Breast Cancer and Molecular

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