CAP Molecular Diagnosis of AML
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List 6 genes associated with Acute Myeloid Leukemia that have been identified by cloning translocation break points
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RUNX1, RUNX1T1, PML, CBFB, ETV6, MLL |
List the 5 main categories of classification of Acute Myeloid Leukemia
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1. AML with recurrent genetic abnormalities, 2. AML with myelodysplasia-related changes, 3. Therapy related myeloid neoplasms, 4. AML, NOS, 5. Myeloid sarcoma |
Give any three translocations identified in AML.
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t(8,21), inv (16), t(15,17), t(9,11), t(6,9), inv(3), t(1,22), mutated NPM1, mutated CEBPA |
What entities are fall under the AML, NOS classification?
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AML with minimal differentiation, AML without maturation, AML with maturation, Acute myelomonocytic leukemia, Acute monoblastic/monocytic leukemia, Acute erythroid leukemias (pure erythroid, erythroleukemia, erythroid/myeloid), Acute Megakaryoblastic leukemia, Acute basophilic leukemia, Acte panmyelosis with myelofibrosis |
List 2 genes which confer a poor prognostic impact vs 2 which confer a good prognostic impact.
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Poor: KIT, FLT3, Good: NPM1, CEBPA |