CAP Molecular Diagnosis of AML

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List 6 genes associated with Acute Myeloid Leukemia that have been identified by cloning translocation break points 

RUNX1, RUNX1T1, PML, CBFB, ETV6, MLL

List the 5 main categories of classification of Acute Myeloid Leukemia 

1. AML with recurrent genetic abnormalities, 2. AML with myelodysplasia-related changes, 3. Therapy related myeloid neoplasms, 4. AML, NOS, 5. Myeloid sarcoma

Give any three translocations identified in AML. 

t(8,21), inv (16), t(15,17), t(9,11), t(6,9), inv(3), t(1,22), mutated NPM1, mutated CEBPA

What entities are fall under the AML, NOS classification? 

AML with minimal differentiation, AML without maturation, AML with maturation, Acute myelomonocytic leukemia, Acute monoblastic/monocytic leukemia, Acute erythroid leukemias (pure erythroid, erythroleukemia, erythroid/myeloid), Acute Megakaryoblastic leukemia, Acute basophilic leukemia, Acte panmyelosis with myelofibrosis

List 2 genes which confer a poor prognostic impact vs 2 which confer a good prognostic impact. 

Poor: KIT, FLT3, Good: NPM1, CEBPA