Sex cord tumour with annular tubules

From Libre Pathology
Revision as of 14:23, 12 May 2016 by Michael (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Sex cord tumour with annular tubules
Diagnosis in short

SCTAT. H&E stain.

LM well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material
Subtypes benign, malignant (very rare)
LM DDx Sertoli-Leydig tumour, granulosa cell tumour, Brenner tumour, gonadoblastoma, neuroendocrine tumour
IHC inhibin +ve, calretinin +ve, pankeratin +ve, EMA -ve, WT-1 +ve
Site ovary - see ovarian tumours

Syndromes Peutz-Jeghers syndrome

Prevalence uncommon
Prognosis usually good (benign)
Clin. DDx other ovarian tumours

Sex cord tumour with annular tubules, abbreviated SCTAT, is an uncommon sex cord tumour.

It is not sex cord tumour with angulated tubules.


  • Associated with Peutz-Jeghers syndrome.[1]
    • Large tumours more likely sporadic.
    • Small tumours more likely Peutz-Jeghers syndrome and incidental.
  • Usually benign.
    • Malignant cases reported.[2]



  • Well-circumscribed nests of cells with nuclei at the periphery.
  • Annular tubules (ring-shaped tubules) with dense hyaline material.







  • Inhibin +ve[6] (3/3[7]).
  • Calretinin +ve (3/3[7]).
  • CD99 +ve.
  • Pankeratin +ve.
  • Vimentin +ve.


See also


  1. Purohit, RC.; Alam, SZ. (Mar 1980). "Sex cord tumour of the ovary with annular tubules (SCTAT).". Histopathology 4 (2): 147-54. PMID 7358344.
  2. Lele, SM.; Sawh, RN.; Zaharopoulos, P.; Adesokan, A.; Smith, M.; Linhart, JM.; Arrastia, CD.; Krigman, HR. (Apr 2000). "Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report.". Mod Pathol 13 (4): 466-70. doi:10.1038/modpathol.3880079. PMID 10786816.
  3. URL: Accessed on: 6 August 2011.
  4. Young, RH.; Welch, WR.; Dickersin, GR.; Scully, RE. (Oct 1982). "Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.". Cancer 50 (7): 1384-402. PMID 7104978.
  5. Nosov, V.; Park, S.; Rao, J.; Memarzadeh, S. (Oct 2009). "Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report.". Fertil Steril 92 (4): 1497.e5-8. doi:10.1016/j.fertnstert.2009.07.1002. PMID 19703688.
  6. Guerrieri, C.; Frånlund, B.; Malmström, H.; Boeryd, B. (Jul 1998). "Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7.". Int J Gynecol Pathol 17 (3): 266-71. PMID 9656124.
  7. 7.0 7.1 7.2 7.3 Deavers, MT.; Malpica, A.; Liu, J.; Broaddus, R.; Silva, EG. (Jun 2003). "Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin.". Mod Pathol 16 (6): 584-90. doi:10.1097/01.MP.0000073133.79591.A1. PMID 12808064.
  8. Oliva E, Garcia-Miralles N, Vu Q, Young RH (October 2007). "CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases". Int. J. Gynecol. Pathol. 26 (4): 359–67. doi:10.1097/PGP.0b013e318064511c. PMID 17885484.