Sertoli cell tumour

Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis.

General

• Arises from Sertoli cells (AKA nurse cells).

May be seen in several syndrome - esp. if there is calcification:

• Carney complex.
• Peutz-Jeghers syndrome.

Microscopic

Features:

• Groups of cells in cords or trabeculae (beam-like arrangement).
• Cells have:
  • Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
  • Slightly irregular nucleoli.
  • Granular irregular appearing chromatin.

Negatives:

• Mitoses are rare.
• No significant nuclear atypia.

DDx:

• Granulosa cell tumour - may be very similar. Often has nuclear grooves.
• Epithelioid adenomatoid tumour.
• Sertoli cell nodule.

Images

• 

  Sertoli cell tumour - high mag. (WC)

• 

  Sertoli cell tumour - low mag. (WC)

www:

• Sertoli cell tumour with calcification in Carney complex - several images (upmc.edu).

IHC

• Alpha-inhibin +ve. (???)

See also

• Leydig cell tumour.
• Sertoli-Leydig tumour.
• Testis.