Difference between revisions of "Sertoli cell tumour"
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'''Sertoli cell tumour''' is a sex cord-stromal tumour typically found in the [[testis]]. | |||
==General== | |||
*Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | |||
May be seen in several syndrome - esp. if there is calcification: | |||
*[[Carney complex]].<ref name=pmid21047926>{{Cite journal | last1 = Libé | first1 = R. | last2 = Horvath | first2 = A. | last3 = Vezzosi | first3 = D. | last4 = Fratticci | first4 = A. | last5 = Coste | first5 = J. | last6 = Perlemoine | first6 = K. | last7 = Ragazzon | first7 = B. | last8 = Guillaud-Bataille | first8 = M. | last9 = Groussin | first9 = L. | title = Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. | journal = J Clin Endocrinol Metab | volume = 96 | issue = 1 | pages = E208-14 | month = Jan | year = 2011 | doi = 10.1210/jc.2010-1704 | PMID = 21047926 }}</ref> | |||
*[[Peutz-Jeghers syndrome]]. | |||
==Microscopic== | |||
Features: | |||
*Groups of cells in ''cords'' or ''trabeculae'' (beam-like arrangement). | |||
*Cells have: | |||
**Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles. | |||
**Slightly irregular nucleoli. | |||
**Granular irregular appearing chromatin. | |||
Negatives: | |||
*Mitoses are rare. | |||
*No significant nuclear atypia. | |||
DDx: | |||
*[[Granulosa cell tumour]] - may be very similar. Often has nuclear grooves. | |||
*Epithelioid [[adenomatoid tumour]]. | |||
*[[Sertoli cell nodule]]. | |||
===Images=== | |||
<gallery> | |||
Image:Sertoli_cell_tumour_high_mag.jpg | Sertoli cell tumour - high mag. (WC) | |||
Image:Sertoli_cell_tumour_low_mag.jpg | Sertoli cell tumour - low mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case275/micro.html Sertoli cell tumour with calcification in Carney complex - several images (upmc.edu)]. | |||
==IHC== | |||
*Alpha-inhibin +ve. (???) | |||
==See also== | |||
*[[Leydig cell tumour]]. | |||
*[[Sertoli-Leydig tumour]]. | |||
*[[Testis]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Testis]] | |||
Revision as of 01:06, 26 December 2013
Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis.
General
- Arises from Sertoli cells (AKA nurse cells).
May be seen in several syndrome - esp. if there is calcification:
Microscopic
Features:
- Groups of cells in cords or trabeculae (beam-like arrangement).
- Cells have:
- Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
- Slightly irregular nucleoli.
- Granular irregular appearing chromatin.
Negatives:
- Mitoses are rare.
- No significant nuclear atypia.
DDx:
- Granulosa cell tumour - may be very similar. Often has nuclear grooves.
- Epithelioid adenomatoid tumour.
- Sertoli cell nodule.
Images
Sertoli cell tumour - high mag. (WC)
Sertoli cell tumour - low mag. (WC)
www:
IHC
- Alpha-inhibin +ve. (???)
See also
References
- ↑ Libé, R.; Horvath, A.; Vezzosi, D.; Fratticci, A.; Coste, J.; Perlemoine, K.; Ragazzon, B.; Guillaud-Bataille, M. et al. (Jan 2011). "Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.". J Clin Endocrinol Metab 96 (1): E208-14. doi:10.1210/jc.2010-1704. PMID 21047926.