Difference between revisions of "Sclerosing adenosis of the breast"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sclerosing_adenosis_--_high_mag.jpg | |||
| Width = | |||
| Caption = Sclerosing_adenosis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini | |||
| Subtypes = | |||
| LMDDx = low-grade [[invasive ductal carcinoma of the breast|ductal carcinoma]], [[tubular adenoma of the breast]], [[adenomyoepithelioma]], breast adenosis | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[breast]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign, increased risk of breast cancer | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Sclerosing adenosis of the breast''', also '''[[sclerosing adenosis]]''', a benign pathology of the breast associated with an increased risk of malignancy. | |||
==General== | |||
*Can look like [[Invasive ductal carcinoma of the breast|ductal carcinoma]]. | |||
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular proliferation). | |||
**Think ''scaring'' + ''many glands packed together''. | |||
Management: | |||
*Follow-up - no further treatment.<ref>URL: [http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions]. Accessed on: 30 April 2012.</ref> | |||
==Microscopic== | |||
Features: | |||
*Acini are smaller than usual and there are more of them. | |||
**Acini often slit-like. | |||
*Fibrosis (scleroses) - pink on H&E surrounds the acini. | |||
**Can mimic a [[desmoplastic reaction]]. | |||
Notes: | |||
*The acini should: | |||
**Be in lobular arrangements, i.e. in groups (benign appearance at low power) - '''key feature'''. | |||
**Have two cell layers like well-behaved breast glands do. | |||
DDx: | |||
*Low-grade [[Invasive ductal carcinoma of the breast|ductal carcinoma]]. | |||
*[[Tubular adenoma of the breast]]. | |||
*[[Adenomyoepithelioma]].<ref name=chu>Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: [http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf]. Accessed on: 28 April 2012.</ref> | |||
*Breast adenosis - should have visble lumens. | |||
===Images=== | |||
<gallery> | |||
Image: Sclerosing adenosis -- low mag.jpg | SA - low mag. (WC) | |||
Image: Sclerosing adenosis -- intermed mag.jpg | SA - intermed. mag. (WC) | |||
Image: Sclerosing adenosis -- high mag.jpg | SA - high mag. (WC) | |||
Image: Sclerosing adenosis -- very high mag.jpg | SA - very high mag. (WC) | |||
</gallery> | |||
==See also== | |||
*[[Breast pathology]]. | |||
*[[Sclerosing adenosis]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | |||
[[Category:Breast pathology]] |
Latest revision as of 10:31, 8 September 2016
Sclerosing adenosis of the breast, also sclerosing adenosis, a benign pathology of the breast associated with an increased risk of malignancy.
Sclerosing adenosis of the breast | |
---|---|
Diagnosis in short | |
![]() Sclerosing_adenosis. H&E stain. | |
| |
LM | increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini |
LM DDx | low-grade ductal carcinoma, tubular adenoma of the breast, adenomyoepithelioma, breast adenosis |
Site | breast |
| |
Prevalence | common |
Prognosis | benign, increased risk of breast cancer |
General
- Can look like ductal carcinoma.
- Derived from sclerosing[1] (hardening) and adenosis (glandular proliferation).
- Think scaring + many glands packed together.
Management:
- Follow-up - no further treatment.[2]
Microscopic
Features:
- Acini are smaller than usual and there are more of them.
- Acini often slit-like.
- Fibrosis (scleroses) - pink on H&E surrounds the acini.
- Can mimic a desmoplastic reaction.
Notes:
- The acini should:
- Be in lobular arrangements, i.e. in groups (benign appearance at low power) - key feature.
- Have two cell layers like well-behaved breast glands do.
DDx:
- Low-grade ductal carcinoma.
- Tubular adenoma of the breast.
- Adenomyoepithelioma.[3]
- Breast adenosis - should have visble lumens.
Images
See also
References
- ↑ URL: http://dictionary.reference.com/browse/sclerosis. Accessed on: 16 March 2011.
- ↑ URL: http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions. Accessed on: 30 April 2012.
- ↑ Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.