Difference between revisions of "Sclerosing adenosis of the breast"

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#redirect [[Breast pathology#Sclerosing adenosis]]
'''Sclerosing adenosis of the breast''', also '''sclerosing adenosis''', a benign pathology of the breast associated with an increased risk of malignancy.
 
==General==
*Can be scary... can look like [[ductal carcinoma]].
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular enlargement).
**Think ''scaring'' + ''lotsa glands'' and you're pretty close.
*Management: follow-up, no further treatment.<ref>URL: [http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions]. Accessed on: 30 April 2012.</ref>
==Microscopic==
Features:
*Acini are smaller than usual and there are more of them.
**Acini often slit-like.
*Fibrosis (scleroses) - pink on H&E surrounds the acini.
**Can mimic a [[desmoplastic reaction]].
 
Notes:
*The acini should:
**Be in lobular arrangements, i.e. in groups (benign appearance at low power) - '''key feature'''.
**Have two cell layers like well-behaved breast glands do.
 
DDx:
*Low-grade [[Invasive ductal carcinoma of the breast|ductal carcinoma]].
*[[Tubular adenoma of the breast]].
*[[Adenomyoepithelioma]].<ref name=chu>Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: [http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf]. Accessed on: 28 April 2012.</ref>
*Breast adenosis - should have visble lumens.
 
==See also==
*[[Breast pathology]].
*[[Sclerosing adenosis]].
 
==References==
{{Reflist|1}}
 
[[Category:Diagnosis]]
[[Category:Breast pathology]]

Revision as of 05:30, 22 June 2016

Sclerosing adenosis of the breast, also sclerosing adenosis, a benign pathology of the breast associated with an increased risk of malignancy.

General

  • Can be scary... can look like ductal carcinoma.
  • Derived from sclerosing[1] (hardening) and adenosis (glandular enlargement).
    • Think scaring + lotsa glands and you're pretty close.
  • Management: follow-up, no further treatment.[2]

Microscopic

Features:

  • Acini are smaller than usual and there are more of them.
    • Acini often slit-like.
  • Fibrosis (scleroses) - pink on H&E surrounds the acini.

Notes:

  • The acini should:
    • Be in lobular arrangements, i.e. in groups (benign appearance at low power) - key feature.
    • Have two cell layers like well-behaved breast glands do.

DDx:

See also

References

  1. ↑ URL: http://dictionary.reference.com/browse/sclerosis. Accessed on: 16 March 2011.
  2. ↑ URL: http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions. Accessed on: 30 April 2012.
  3. ↑ Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.
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