Difference between revisions of "S-100"

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{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image      = Mammary_analogue_secretory_carcinoma_(S100immunohistochemstry,_low_power).jpg
| Width      =
| Caption    = S-100 staining in a [[secretory carcinoma of the salivary gland]].
| Abbrev    =
| Synonyms  =
| Similar    =
| Clones    =     
| Use        = [[malignant melanoma]], assess [[perineural invasion]], undifferentiated malignancy
| Subspecial = 
| Pattern    = nucleus and cytoplasm
| Positive  = benign: nerves, adipose tissue; tumour/other: [[granular cell tumour]], [[Rosai-Dorfman disease]]; malignant: [[malignant melanoma]], [[clear cell sarcoma]], [[malignant peripheral nerve sheath tumour]]
| Negative  =
| Other      =
}}
'''S-100''', also '''S100''', is a commonly used [[immunostain]].  It marks nerves.
'''S-100''', also '''S100''', is a commonly used [[immunostain]].  It marks nerves.


<!-- Dabbs' IHC book uses 'S-100' -->
<!-- Dabbs' IHC book uses 'S-100' as opposed to 'S100' -->
==Positive==
==Positive==
*Nerves.
*Nerves.
*Interdigitating dendritic cells.<ref>{{Cite journal  | last1 = Mesquita | first1 = RA. | last2 = de Araújo | first2 = VC. | last3 = Paes | first3 = RA. | last4 = Nunes | first4 = FD. | last5 = de Souza | first5 = SC. | title = Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas. | journal = J Appl Oral Sci | volume = 17 | issue = 3 | pages = 248-53 | month =  | year =  | doi =  | PMID = 19466261 }}
*[[Schwannoma]].
*Mature adipose tissue.
*Interdigitating dendritic cells.<ref name=pmid19466261>{{Cite journal  | last1 = Mesquita | first1 = RA. | last2 = de Araújo | first2 = VC. | last3 = Paes | first3 = RA. | last4 = Nunes | first4 = FD. | last5 = de Souza | first5 = SC. | title = Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas. | journal = J Appl Oral Sci | volume = 17 | issue = 3 | pages = 248-53 | month =  | year =  | doi =  | PMID = 19466261 }}
</ref>
</ref>
*[[Langerhans cell histiocytosis]].
*[[Rosai-Dorfman disease]].
*[[Chordoma]] - also keratin positive ([[AE1/AE3]], [[CK19]], [[CAM5.2]]).<ref name=pmid24296480>{{Cite journal  | last1 = Shen | first1 = J. | last2 = Shi | first2 = Q. | last3 = Lu | first3 = J. | last4 = Wang | first4 = DL. | last5 = Zou | first5 = TM. | last6 = Yang | first6 = HL. | last7 = Zhu | first7 = GQ. | title = Histological study of chordoma origin from fetal notochordal cell rests. | journal = Spine (Phila Pa 1976) | volume = 38 | issue = 25 | pages = 2165-70 | month = Dec | year = 2013 | doi = 10.1097/BRS.0000000000000010 | PMID = 24296480 }}</ref>
*[[Granular cell tumour]].
*[[Nodal nevus]].
===Malignant tumours===
*[[Malignant melanoma]] - almost 100% [[sensitivity|sensitive]].
*[[Malignant melanoma]] - almost 100% [[sensitivity|sensitive]].
*[[Malignant peripheral nerve sheath tumour]].
*[[Clear cell sarcoma]].
*[[Mammary analogue secretory carcinoma]].


==See also==
==See also==

Latest revision as of 19:29, 11 February 2021

S-100
Immunostain in short

S-100 staining in a secretory carcinoma of the salivary gland.
Use malignant melanoma, assess perineural invasion, undifferentiated malignancy
Normal staining pattern nucleus and cytoplasm
Positive benign: nerves, adipose tissue; tumour/other: granular cell tumour, Rosai-Dorfman disease; malignant: malignant melanoma, clear cell sarcoma, malignant peripheral nerve sheath tumour

S-100, also S100, is a commonly used immunostain. It marks nerves.

Positive

Malignant tumours

See also

References

  1. Mesquita, RA.; de Araújo, VC.; Paes, RA.; Nunes, FD.; de Souza, SC.. "Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas.". J Appl Oral Sci 17 (3): 248-53. PMID 19466261.
  2. Shen, J.; Shi, Q.; Lu, J.; Wang, DL.; Zou, TM.; Yang, HL.; Zhu, GQ. (Dec 2013). "Histological study of chordoma origin from fetal notochordal cell rests.". Spine (Phila Pa 1976) 38 (25): 2165-70. doi:10.1097/BRS.0000000000000010. PMID 24296480.