Nodal nevus

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Nodal nevus
Diagnosis in short

Synonyms capsular nevus, benign nevus cells in lymph node

LM bland nevus cells (lack prominent nucleoli, nuclear pleomorphism, proliferative activity)
LM DDx malignant melanoma
IHC S-100 +ve
Gross usually not apparent
Site lymph node

Signs none
Prevalence rare
Prognosis benign
Clin. DDx lymph node metastasis
Treatment none or follow-up

Nodal nevus, also capsular nevus, is benign lymph node finding that can be mistaken for malignant melanoma.[1]

Nevus in lymph node and benign nevus cells in lymph node redirect here.



  • Usually not apparent.



  • Nevus cells with bland cytomorphology.
    • Lack size variation, nucleoli.
    • Non-proliferative.


  • No standardized criteria.[3]





  • S-100 +ve.


  1. Lee, JJ.; Granter, SR.; Laga, AC.; Saavedra, AP.; Zhan, Q.; Guo, W.; Xu, S.; Murphy, GF. et al. (Feb 2015). "5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies.". Mod Pathol 28 (2): 218-29. doi:10.1038/modpathol.2014.99. PMID 25081754.
  2. Prieto, VG. (09 2017). "Sentinel Lymph Nodes in Cutaneous Melanoma.". Clin Lab Med 37 (3): 417-430. doi:10.1016/j.cll.2017.05.002. PMID 28802493.
  3. 3.0 3.1 3.2 Davis, J.; Patil, J.; Aydin, N.; Mishra, A.; Misra, S. (2016). "Capsular nevus versus metastatic malignant melanoma - a diagnostic dilemma.". Int J Surg Case Rep 29: 20-24. doi:10.1016/j.ijscr.2016.10.040. PMID 27810606.