Difference between revisions of "Radiation colitis"
Jump to navigation
Jump to search
(tweak) |
|||
| Line 1: | Line 1: | ||
'''Radiation colitis''' is inflammation of the [[colon]] due to radiation. | '''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. | ||
==General== | ==General== | ||
*Diagnosis should be supported by clinical history. | *[[Diagnosis]] should be supported by the clinical history. | ||
General DDx for a [[colitis]]: | |||
*[[ | *Idiopathic, e.g. [[inflammatory bowel disease]]. | ||
*Infection. | *[[Infectious colitis|Infection]]. | ||
*[[Ischemic colitis|Ischemia]]. | *[[Ischemic colitis|Ischemia]]. | ||
*Radiation. | *Radiation. | ||
Revision as of 23:23, 15 April 2013
Radiation colitis is inflammation of the colon due to radiation. It is usually iatrogenic.
General
- Diagnosis should be supported by the clinical history.
General DDx for a colitis:
- Idiopathic, e.g. inflammatory bowel disease.
- Infection.
- Ischemia.
- Radiation.
Gross
- Superficial bowel wall injury - shallow ulceration.[1]
- Telangiectatic lesions.
Image:
Microscopic
Features - acute:[1]
- Mucosal changes:
- Necrosis of epithelium.
- "Ghost cells" = cells without nuclei.
- Hemorrhage.
- Necrosis of epithelium.
- Submucosa edema with neutrophilic infiltrate.
- +/-Fibrin thrombi.
Features - chronic:
- Nuclear atypia - esp. of the stromal cells.
- The epithelium is shed and regenerates... therefore usually does not have the changes.
- Fibrosis - esp. of the submucosa.
DDx:
- Ischemic colitis.
- Inflammatory bowel disease.
- Infectious colitis.
Images:
See also
References
- ↑ 1.0 1.1 1.2 Yano, Y.; Yao, H.; Aoyagi, K.; Kawakubo, K.; Nakamura, S.; Doi, K.; Ibayashi, S.; Fujishima, M. (Sep 1997). "Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats.". Gut 41 (3): 354-7. PMID 9378391.
- ↑ 2.0 2.1 Nielsen, OH.; Vainer, B.; Rask-Madsen, J. (Jan 2008). "Non-IBD and noninfectious colitis.". Nat Clin Pract Gastroenterol Hepatol 5 (1): 28-39. doi:10.1038/ncpgasthep1005. PMID 18174905.