Difference between revisions of "Plasma cell"

From Libre Pathology
Jump to navigation Jump to search
Line 14: Line 14:
***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.
***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.


Images:
===Images===
*[http://commons.wikimedia.org/wiki/File:Plasmacytoma_ultramini1.jpg Plasma cells (WC)].
<gallery>
Image: Multinucleated plasma cell -- high mag.jpg | Plasma cells - high mag.
Image: Multinucleated plasma cell -- very high mag.jpg | Plasma cells - very high mag.
Image: Multinucleated plasma cell -- extremely high mag.jpg | Plasma cells - extremely high mag.
</gallery>
<gallery>
Image:Plasmacytoma_ultramini1.jpg | Plasma cells in a plasmacytoma. (WC)
</gallery>


==Neoplasia==
==Neoplasia==

Revision as of 01:35, 21 November 2013

The plasma cell is white blood cell that produces antibodies.

Microscopic

Features:

  • Ovoid intermediate-small cell size ~ 12 micrometers:
  • Eccentric nucleus.
    • Nucleus usu. hugs the cell membrane.
    • "Clock-face" chromatin pattern.
      • Small dots symmetrically rim the nuclear membrane - like the numbers on a clock.
  • Abundant cytoplasm.
    • Nucleus-to-cytoplasm ratio ~1:2
    • Perinuclear hof (prominent Gogli apparatus).
      • Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.

Images

Neoplasia

Neoplasms derived from plasma cell are called plasma cell neoplasms.

IHC

Others:

  • CD19 -ve.
  • CD20 -ve
  • CD56 -ve.

Lesions where plasma cells are important

Selected lesions with plasma cells

Neoplasms:

Inflammatory conditions:

Infectious:

Plasma cells are absent

See also

References

  1. 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 554. ISBN 978-0781765275.
  2. Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L (July 2010). "Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease". Inflamm Bowel Dis. doi:10.1002/ibd.21376. PMID 20629103.