Noninvasive follicular thyroid neoplasm with papillary-like nuclear features

From Libre Pathology
Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Noninvasive follicular thyroid neoplasm with papillary like-nuclear features is a proposed term for encapsulated thyroid tumours with papillary-like features. It is abbreviated NIFTP[1] and pronounced nift-pee.

The term NIFTP is a compromise of sorts and probably best described as a contrived acronym that can easily be pronounced; NIFTNPLNF isn't catchy or easy to pronounce.

If one wants to make it a backronym, NIFTP could be noninvasive follicular tumour, papillary-like.

General

  • Encapsulated thyroid tumours with nuclear papillary-like features without invasion have a good prognosis, and labelling them as cancer is probably not unwarranted.[2]
  • Can only be diagnosed on excisional specimens where the entire tumour capsule is sampled.[citation needed]

Microscopic

Features of NIFTP:[3]

  • Major features - all required for diagnosis:
    • Nuclear features of papillary thyroid carcinoma - 2 or 3 of the following:
      1. Nuclear membranes changes (irregular membrane contours, nuclear grooves, nuclear pseudoinclusions).
      2. Size and shape changes (enlargement, elongation, overlapping).
      3. Chromatin changes (clearing, chromatin margination, glass-like appearance).
    • Encapsulated or well-demarcated.
    • Follicular pattern.
  • Minor features:
    • Intratumoural fibrosis, eosinophilic and paucicellular.
    • Clefting of follicules from surrounding stroma.
    • Multinucleated cells.
    • Dark colloid.

Features that exclude the diagnosis of NIFTP:[3]

DDx:

Images

  • NIFTP. (WC/Soca1zim)

  • NIFTP. (WC/Soca1zim)

See also

References

  1. ↑ URL: http://lesterthompsonmd.com/medical-techniques/2016-scpmg-thyroid-niftp/. Accessed on: 26 March 2016.
  2. ↑ Ganly, I.; Wang, L.; Tuttle, RM.; Katabi, N.; Ceballos, GA.; Harach, HR.; Ghossein, R. (May 2015). "Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumors: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant.". Hum Pathol 46 (5): 657-64. doi:10.1016/j.humpath.2015.01.010. PMID 25721865.
  3. ↑ 3.0 3.1 URL: http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf. Accessed on: 5 April 2016.

External links

Retrieved from "https://librepathology.org/w/index.php?title=Noninvasive_follicular_thyroid_neoplasm_with_papillary-like_nuclear_features&oldid=44370"