Difference between revisions of "Noninvasive follicular thyroid neoplasm with papillary-like nuclear features"

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==Microscopic==
==Microscopic==
Features of NIFTP:<ref name=thompson>URL: [http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf]. Accessed on: 5 April 2016.</ref>
Features of NIFTP:<ref name=thompson>URL: [http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf]. Accessed on: 5 April 2016.</ref>
*Major features:
*Major features - all required for diagnosis:
**Nuclear features of papillary thyroid carcinoma - 2 or 3 of the following:
**Nuclear features of papillary thyroid carcinoma - 2 or 3 of the following:
**#Nuclear membranes changes (irregular membrane contours, nuclear grooves, nuclear pseudoinclusions).
**#Nuclear membranes changes (irregular membrane contours, nuclear grooves, nuclear pseudoinclusions).
Line 19: Line 19:
**Follicular pattern.
**Follicular pattern.
*Minor features:
*Minor features:
**Dark colloid.
**Intratumoural fibrosis, eosinophilic and paucicellular.
**Intratumoural fibrosis, eosinophilic and paucicellular.
**Clefting of follicules from surrounding stroma.
**Clefting of follicules from surrounding stroma.
**Multinucleated cells.
**Multinucleated cells.
**Dark colloid.


Features that exclude the diagnosis of NIFTP:<ref name=thompson/>
Features that exclude the diagnosis of NIFTP:<ref name=thompson/>
*True papillae >1% of the tumour.
*True papillae >1% within the tumour.
*[[Psammoma bodies]].
*[[Psammoma bodies]].
*Infiltration of the capsule ''or'' an infiltrative border.
*Infiltration of the capsule ''or'' an infiltrative border.

Revision as of 17:52, 5 April 2016

Noninvasive follicular thyroid neoplasm with papillary like-nuclear features is a proposed term for encapsulated thyroid tumours with papillary-like features. It is abbreviated NIFTP[1] and pronounced nift-pee.

The term NIFTP is a compromise of sorts and probably best described as a contrived acronym that can easily be pronounced; NIFTNPLNF isn't catchy or easy to pronounce.

If one wants to make it a backronym, NIFTP could be noninvasive follicular tumour, papillary-like.

General

  • Encapsulated thyroid tumours with nuclear papillary-like features without invasion have a good prognosis, and labelling them as cancer is probably not unwarranted.[2]
  • Can only be diagnosed on excisional specimens where the entire tumour capsule is sampled.[citation needed]

Microscopic

Features of NIFTP:[3]

  • Major features - all required for diagnosis:
    • Nuclear features of papillary thyroid carcinoma - 2 or 3 of the following:
      1. Nuclear membranes changes (irregular membrane contours, nuclear grooves, nuclear pseudoinclusions).
      2. Size and shape changes (enlargement, elongation, overlapping).
      3. Chromatin changes (clearing, chromatin margination, glass-like appearance).
    • Encapsulated or well-demarcated.
    • Follicular pattern.
  • Minor features:
    • Intratumoural fibrosis, eosinophilic and paucicellular.
    • Clefting of follicules from surrounding stroma.
    • Multinucleated cells.
    • Dark colloid.

Features that exclude the diagnosis of NIFTP:[3]

DDx:

See also

References

  1. ↑ URL: http://lesterthompsonmd.com/medical-techniques/2016-scpmg-thyroid-niftp/. Accessed on: 26 March 2016.
  2. ↑ Ganly, I.; Wang, L.; Tuttle, RM.; Katabi, N.; Ceballos, GA.; Harach, HR.; Ghossein, R. (May 2015). "Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumors: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant.". Hum Pathol 46 (5): 657-64. doi:10.1016/j.humpath.2015.01.010. PMID 25721865.
  3. ↑ 3.0 3.1 URL: http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf. Accessed on: 5 April 2016.

External links

Retrieved from "https://librepathology.org/w/index.php?title=Noninvasive_follicular_thyroid_neoplasm_with_papillary-like_nuclear_features&oldid=43563"