Difference between revisions of "Malignant histiocytosis"

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'''Histiocytic sarcoma''' is a rare tumour.
'''Malignant histiocytosis''' is a rare malignant type of [[histiocytosis]].
 
'''Histiocytic sarcoma''' is considered by many as a synonym;<ref>{{Cite journal  | last1 = Low | first1 = SE. | last2 = Stafford | first2 = JS. | title = Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture. | journal = J Clin Pathol | volume = 59 | issue = 7 | pages = 770-2 | month = Jul | year = 2006 | doi = 10.1136/jcp.2005.027870 | PMID = 16803951 }}</ref> it redirects to this article.


==General==
==General==
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==Microscopic==
==Microscopic==
Features:<ref name=pmid17324277>{{Cite journal  | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue =  | pages = 7 | month =  | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 }}</ref>
Features:<ref name=pmid17324277>{{Cite journal  | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue =  | pages = 7 | month =  | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | PMC = 1808440 | URL = http://www.diagnosticpathology.org/content/2/1/7 }}</ref>
*Malignant histiocyte-like cells:
*Malignant histiocyte-like cells:
**Nuclear atypia.
**Nuclear atypia.
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Image:
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/figure/F2/ HS (nih.gov)].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/figure/F2/ HS (nih.gov)].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/figure/F3/ HS (nih.gov)].


==IHC==
==IHC==
Features:<ref name=pmid17324277>
Features:<ref name=pmid17324277/>
*CD68 +ve.
*CD68 +ve.


==See also==
==See also==
*[[Histiocytoses]].
*[[Histiocytoses]].
*[[Classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages]].
*[[Sarcoma]].
*[[Sarcoma]].



Latest revision as of 19:29, 23 July 2019

Malignant histiocytosis is a rare malignant type of histiocytosis.

Histiocytic sarcoma is considered by many as a synonym;[1] it redirects to this article.

General

  • Uncommon.

Microscopic

Features:[2]

  • Malignant histiocyte-like cells:
    • Nuclear atypia.
    • Abundant eosinophilic cytoplasm.

DDx:

Image:

IHC

Features:[2]

  • CD68 +ve.

See also

References

  1. Low, SE.; Stafford, JS. (Jul 2006). "Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture.". J Clin Pathol 59 (7): 770-2. doi:10.1136/jcp.2005.027870. PMID 16803951.
  2. 2.0 2.1 Alexiev, BA.; Sailey, CJ.; McClure, SA.; Ord, RA.; Zhao, XF.; Papadimitriou, JC. (2007). "Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component.". Diagn Pathol 2: 7. doi:10.1186/1746-1596-2-7. PMC 1808440. PMID 17324277. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808440/.