Difference between revisions of "Invasive breast cancer"

Invasive breast cancer (view source)

36 bytes added , 11:41, 20 March 2015

653

edits

@@ Line 156: / Line 156: @@
 *Overview
+**A category of breast carcinomas defined by gene expression profiling
 **Somewhere between 15-30% of breast carcinomas.
-**A category of breast carcinomas defined by gene expression profiling
 **Can be identified by immunohistochemistry - basal markers (CK14, p63, calponin, SMA)
 **Not derived from myoepithelial cells, merely express a phenotype more in keeping with basal cells than ductal cells
@@ Line 188: / Line 188: @@
 **Basal-like breast cancer is a heterogeneous group.
 **The behaviour of basal-like breast cancer appears to fall into two groups:
-***The tumours that do not metastasise have a better prognosis than other types of breast carcinoma.
+***The tumours that are by nature low grade (ie adenoid cystic carcinoma) and/or do not metastasise have a better prognosis than other types of breast carcinoma.
-***Tumours with early metastasis may behave more aggressively
+***The tumours with early metastasis that may behave more aggressively
-****Hematogenous spread -greater tendency to metastasise to visceral sites associated with poorer prognosis (such as lung and brain)  instead of to nodes and bone.
+****Hematogenous spread -greater tendency to metastasise to visceral sites (notably lung and brain) instead of to nodes and bone.
 **Many have a complete response to chemotherapy and survival rates similar to typical breast cancer
 **Non-complete response to chemotherapy is associated with low survival at 5 years.